9-oxo-fluorene-2,7-dicarbonyl chloride | 36421-08-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9-oxo-fluorene-2,7-dicarbonyl chloride
• 英文别名: 9-Oxo-fluoren-2,7-dicarbonylchlorid；Fluorenon-2.7-dicarbonsaeuredichlorid；9-oxofluorene-2,7-dicarbonyl chloride
• CAS: 36421-08-6
• 化学式: C₁₅H₆Cl₂O₃
• 分子量: 305.117
• InChiKey: VJEQOIVJDCMYDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  9-oxo-fluorene-2,7-dicarbonyl chloride 在 氨 、 N,N-二甲基甲酰胺 、 三氯氧磷 作用下， 以 苯 为溶剂， 生成 2,7-Dicyanofluorenon
  参考文献：
  名称：

  Ferranti; Chiarini; Garuti, Farmaco, Edizione Scientifica, 1982, vol. 37, # 3, p. 199 - 204

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基-4,5-二甲氧基苯甲腈 在 sodium hydroxide 、 sodium hypochlorite 、 氯化亚砜 作用下， 生成 9-oxo-fluorene-2,7-dicarbonyl chloride
  参考文献：
  名称：

  Electron acceptors derived from fluorenecarboxylic acids and their charge-transfer complexes

  摘要：

  DOI：

  10.1021/jo00833a064

文献信息

• Derivatives of 9-phenanthrene
  申请人：Richardson-Merrell Inc.

  公开号：US03933893A1

  公开（公告）日：1976-01-20

  Novel bis basic esters of 9-substituted phenanthrene and related 9-oxa and 9-aza derivatives thereof, their preparation and use for the prevention and inhibition of viral infections are disclosed.

  本发明揭示了9-取代菲的新型碱性酯类化合物以及其相关的9-氧杂和9-氮杂衍生物，它们的制备和用于预防和抑制病毒感染的用途。
• Pharmaceutically useful nitrogen containing heterocyclic derivatives
  申请人：Richardson-Merrell Inc.

  公开号：US03937833A1

  公开（公告）日：1976-02-10

  Bis-basic substituted aromatic polycyclic compounds of the following structure are useful in treating conditions of delayed hypersensitivity: ##SPC1## Wherein [W] represents an aromatic polycyclic nucleus selected from fluoranthene, fluorene, fluoren-9-ol, fluoren-9-one, dibenzofuran, dibenzothiophene, carbazole, N-(lower)alkyl carbazole, xanthene, xanthone, thioxanthene, phenoxathiin, or anthraquinone; Y represents carbonyloxy, carbonylthio, oxygen, divalent sulfur or carbonyl with the provisos that when Y is carbonyloxy or carbonylthio, [W] is other than thioxanthene, phenoxathiin or anthraquinone, when Y is oxygen or divalent sulfur, [W] is other than thioxanthene or phenoxathiin, and when Y is carbonyl, [W] is other than fluoren-9-ol or anthraquinone; A represents a straight or branched alkylene chain of from 1 to 6 carbon atoms with the proviso that when Y is carbonyloxy or carbonylthio, A contains at least 2 straight chain carbon atoms, that is, an ethylene radical; R represents hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, phenyl or benzyl; and pharmaceutically useful acid addition salts.

  以下结构的Bis-基取代芳香族多环化合物在治疗延迟型超敏反应方面很有用：##SPC1## 其中[W]代表从荧蒽、芴、芴-9-醇、芴-9-酮、二苯并呋喃、二苯并噻吩、咔唑、N-(较低)烷基咔唑、苯酚氧噻吩或蒽醌中选的芳香族多环核；Y代表羰氧基、羰硫基、氧、二价硫或羰基，但当Y为羰氧基或羰硫基时，[W]不是噻吩、苯酚氧噻吩或蒽醌，当Y为氧或二价硫时，[W]不是噻吩或苯酚氧噻吩，当Y为羰基时，[W]不是芴-9-醇或蒽醌；A代表1至6个碳原子的直链或支链烷基链，但当Y为羰氧基或羰硫基时，A含有至少2个直链碳原子，即乙烯基；R代表氢、1至4个碳原子的直链或支链低级烷基、苯基或苄基；以及药用酸盐。
• Derivatives of 6(5H)-phenanthridinone and a method for preparation
  申请人：Richardson-Merrell Inc.

  公开号：US03953455A1

  公开（公告）日：1976-04-27

  Novel bis basic esters of 9-substituted phenanthrene and related 9-oxa and 9-aza derivatives thereof, their preparation and use for the prevention and inhibition of viral infections are disclosed.

  本发明揭示了9-取代菲和相关的9-氧杂和9-氮杂衍生物的新型双酯类化合物，它们的制备和用于预防和抑制病毒感染的方法。
• Fluorene compounds
  申请人：Richardson-Merrell Inc.

  公开号：US03983124A1

  公开（公告）日：1976-09-28

  Novel 2,7-bis-basic derivatives of fluorene, 9-fluorenol and 9-fluorenone, their preparation and use for the prevention and inhibition of virus infections are disclosed.

  本发明揭示了芴的2,7-双碱基衍生物、9-芴醇和9-芴酮的制备以及它们用于预防和抑制病毒感染的用途。
• Electron acceptors derived from fluorenecarboxylic acids and their charge-transfer complexes
  作者：Theodore Sulzberg、Robert J. Cotter

  DOI：10.1021/jo00833a064

  日期：1970.8