| 479637-20-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 479637-20-2
• 化学式: C₅₃H₇₄O₈
• 分子量: 839.166
• InChiKey: OKNAYQNYYUWFQG-FBAXVEOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.29
• 重原子数：
  61.0
• 可旋转键数：
  32.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  95.84
• 氢给体数：
  2.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 生成 α-[(2R,3R)-2,3-dihydroxynonadecyl] D-galactopyranoside
  参考文献：
  名称：

  Rapid Preparation of Glycolipid Libraries by Cross Metathesis

  摘要：

  A new strategy for the synthesis of a well-defined glycolipid library is presented. A highly selective cross metathesis reaction is used to diversify the lipid moiety of anomerically pure alpha- or beta-glycosides, and subsequent functionalization of the double bond allows further expansion of the diversity. These glycolipids are being investigated for their effect on the immune system, especially the CD1-mediated T-cell activation.

  DOI：

  10.1002/1615-4169(200208)344:6/7<622::aid-adsc622>3.0.co;2-w
• 作为产物：
  描述：

  2-propenyl 2,3,4,6-tetra-O-benzyl-α-D-glactopyranoside 在 Grubbs catalyst first generation AD-mix-α 、 甲基磺酰胺 作用下， 以 二氯甲烷 、 水 、 叔丁醇 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  Rapid Preparation of Glycolipid Libraries by Cross Metathesis

  摘要：

  A new strategy for the synthesis of a well-defined glycolipid library is presented. A highly selective cross metathesis reaction is used to diversify the lipid moiety of anomerically pure alpha- or beta-glycosides, and subsequent functionalization of the double bond allows further expansion of the diversity. These glycolipids are being investigated for their effect on the immune system, especially the CD1-mediated T-cell activation.

  DOI：

  10.1002/1615-4169(200208)344:6/7<622::aid-adsc622>3.0.co;2-w