2-[(5-bromobenzotriazol-1-yl)methoxy]ethyltrimethylsilane | 444103-79-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: 2-[(5-bromobenzotriazol-1-yl)methoxy]ethyltrimethylsilane
• 英文别名: 5-Bromo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzotriazole；2-[(5-bromobenzotriazol-1-yl)methoxy]ethyl-trimethylsilane
• CAS: 444103-79-1
• 化学式: C₁₂H₁₈BrN₃OSi
• 分子量: 328.284
• InChiKey: KOJHRNWNTBDHJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.51
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  39.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[(5-bromobenzotriazol-1-yl)methoxy]ethyltrimethylsilane 在 bis-triphenylphosphine-palladium(II) chloride 9-borabicyclo[3.3.1]nonane dimer 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists

  摘要：

  A novel series of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives were designed and synthesized as GnRH receptor antagonists. SAR studies led to a series of highly active molecules against both the rat and human receptors. Furthermore, one potent compound, 17j, demonstrated dose-dependent LH suppression in castrated rats. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.05.009
• 作为产物：
  描述：

  4-溴邻苯二胺 在 sodium hydride 、 溶剂黄146 、 sodium nitrite 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-[(5-bromobenzotriazol-1-yl)methoxy]ethyltrimethylsilane
  参考文献：
  名称：

  2-Arylindoles as gonadotropin releasing hormone (GnRH) antagonists: optimization of the tryptamine side chain

  摘要：

  A series of 2-arylindoles containing novel heteroaromatic substituents on the tryptamine tether, based on compound 1, was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. Successful modifications of 1 included chain length variation (reduction) and replacement of the pyridine with heteroaromatic groups. These alterations culminated in the discovery of compound 27kk which had excellent in vitro potency and oral efficacy in rodents. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00026-4

文献信息

• Inhibitors of CYP 17
  申请人：BOCK Mark G.

  公开号：US20100331326A1

  公开（公告）日：2010-12-30

  The present invention provides compounds of Formula (I) and (II), or a pharmaceutically acceptable salts thereof, where R 53 , R 54 , p, q, and n are as defined herein. The compounds of the present invention have been found to be useful as 17α-hydroxylase/C 17,20 -lyase inhibitors.

  本发明提供了公式(I)和(II)的化合物，或其药学上可接受的盐，其中R53、R54、p、q和n如本文所定义。本发明的化合物已被发现可用作17α-羟化酶/C17,20-裂解酶抑制剂。
• INHIBITORS OF CYP 17
  申请人：BOCK Mark Gary

  公开号：US20140228394A1

  公开（公告）日：2014-08-14

  The present invention provides compounds of Formula (I) and (II), or a pharmaceutically acceptable salts thereof, where R 53 , R 54 , p, q, and n are as defined herein. The compounds of the present invention have been found to be useful as 17α-hydroxylase/C 17,20 -lyase inhibitors.

  本发明提供了式(I)和(II)的化合物，或其药学上可接受的盐，其中R53、R54、p、q和n的定义如本文所述。本发明的化合物已被发现可用作17α-羟化酶/C17,20-裂解酶抑制剂。
• USRE045173E1
  申请人：——

  公开号：——

  公开（公告）日：——
• PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS
  申请人：[en]AURON THERAPEUTICS, INC.

  公开号：WO2024050078A1

  公开（公告）日：2024-03-07

  Provided herein are heterocyclic phenyl compounds useful as degraders of KAT2, as well as compositions and methods of use thereof.