羟甲磺酸二甲磺酸 | 84094-94-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - Pyrroloazepines
• 中文名称: 羟甲磺酸二甲磺酸
• 英文名称: Hymenialdisine Methanoate
• 英文别名: (4Z)-4-(2-amino-5-oxo-1H-imidazol-4-ylidene)-2-bromo-1,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one;methanol
• CAS: 84094-94-0
• 化学式: C12H14BrN5O3
• 分子量: 356.18
• InChiKey: HRCPXWHLWFTZJA-ZULQGGHCSA-N

物化性质

• 熔点：
  >245°C (dec.)
• 溶解度：
  可溶于DMSO（轻微）、甲醇（非常轻微）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.33
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  133
• 氢给体数：
  5
• 氢受体数：
  3

制备方法与用途

用途 

A potent inhibitor of a variety of kinases including MEK-1, GSK-3β, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations. A marine sponge alkaloid, a natural product.

文献信息

• Use of hymenialdisine or derivatives thereof in the manufacture of medicaments
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

  公开号：EP1106180A1

  公开（公告）日：2001-06-13

  The invention relates to the use of hymenialdisine or derivatives thereof of formula I in which R1 and R2, identical or different, represent H or Br, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in inhibiting cyclin dependent kinases, GSK-3β and casein kinase 1. Application for preventing and treating neurodegenerative disorders such as Alzheimer's disease, diabetes, inflammatory pathologies and cancers.

  本发明涉及式 I 中 R1 和 R2（相同或不同）代表 H 或 Br 的海米二嗪或其衍生物或其药学上可接 受的盐在制造用于抑制细胞周期蛋白依赖性激酶、GSK-3β 和 GSK-3β 的药物中的用途 其中 R1 和 R2（相同或不同）代表 H 或 Br 或其药学上可接受的盐，用于制造抑制细胞周期蛋白依赖性激酶、GSK-3β 和酪蛋白激酶 1 的药物。 应用于预防和治疗神经退行性疾病，如阿尔茨海默病、糖尿病、炎症性病变和癌症。
• Hymenialdisine or derivatives thereof in the manufacture of medicaments
  申请人：——

  公开号：US20030105075A1

  公开（公告）日：2003-06-05

  The invention relates to the use of hymenialdisine or derivatives thereof of formula (I) in which R1 and R2, identical or different, represent H or Br, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in inhibiting acceptable salt thereof, in the manufacture of a medicament for use in inhibiting cycline dependent kineases, GSK-3&bgr; and casein kinase 1. Application for preventing and treating neurodegenerative disorders, diabetes, inflammatory pathologies and cancers.

  本发明涉及式（I）中R1和R2（相同或不同）代表H或Br的海明二辛或其衍生物或其药学上可接受的盐在制造用于抑制环依赖性激酶、GSK-3&bgr；和酪蛋白激酶1的药物中的用途。应用于预防和治疗神经退行性疾病、糖尿病、炎症性病变和癌症。
• USE OF HYMENIALDISINE OR DERIVATIVES THEREOF IN THE MANUFACTURE OF MEDICAMENTS
  申请人：CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS)

  公开号：EP1235578A2

  公开（公告）日：2002-09-04
• US7098204B2
  申请人：——

  公开号：US7098204B2

  公开（公告）日：2006-08-29
• [EN] USE OF HYMENIALDISINE OR DERIVATIVES THEREOF IN THE MANUFACTURE OF MEDICAMENTS<br/>[FR] UTILISATION D'HYMENIALDISINE OU DE SES DERIVES POUR LA FABRICATION DE MEDICAMENTS
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2001041768A2

  公开（公告）日：2001-06-14

  The invention relates to the use of hymenialdisine or derivatives thereof of formula (I) in which R1 and R2, identical or different, represent H or Br, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in inhibiting acceptable salt thereof, in the manufacture of a medicament for use in inhibiting cycline dependent kineases, GSK-3β and casein kinase 1. Application for preventing and treating neurodegenerative disorders, including Alzheimers disease, diabetes, inflammatory pathologies and cancers.