(2R,3aR,6aR)-methyl 2-(bis(tert-butoxycarbonyl)amino)-5-methyleneoctahydropentalene-3a-carboxylate | 1416177-65-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R,3aR,6aR)-methyl 2-(bis(tert-butoxycarbonyl)amino)-5-methyleneoctahydropentalene-3a-carboxylate
• 英文别名: methyl (2R,3aR,6aR)-2-[bis[(2-methylpropan-2-yl)oxycarbonyl]amino]-5-methylidene-1,2,3,4,6,6a-hexahydropentalene-3a-carboxylate
• CAS: 1416177-65-5
• 化学式: C₂₁H₃₃NO₆
• 分子量: 395.496
• InChiKey: SYHFONVRBJJTED-VTJXTGGHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  82.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2R,3aR,6aR)-methyl 2-(bis(tert-butoxycarbonyl)amino)-5-methyleneoctahydropentalene-3a-carboxylate 在 水 、 臭氧 、 sodium sulfate 、 对甲苯磺酰肼 、 三氟乙酸 、 lithium hydroxide 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 为溶剂， 生成 (2R,3aR,6aR)-2-(tert-butoxycarbonylamino)octahydropentalene-3a-carboxylic acid
  参考文献：
  名称：

  Novel 2-aminooctahydrocyclopentalene-3a-carboxamides as potent CCR2 antagonists

  摘要：

  Novel CCR2 antagonists with a novel 2-aminooctahydrocyclopentalene-3a-carboxamide scaffold were designed. SAR studies led to a series of potent compounds. For example, compound 51 had a good PK profile in both dog and monkey, and exhibited excellent efficacy when dosed orally in an inflammation model in hCCR2 KI mice. In addition, an asymmetric synthesis to the core structures was developed. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.10.069
• 作为产物：
  描述：

  帕拉米韦杂质42 在 4-二甲氨基吡啶 、 三异丙基亚磷酸酯 、 palladium diacetate 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 生成 (2R,3aR,6aR)-methyl 2-(bis(tert-butoxycarbonyl)amino)-5-methyleneoctahydropentalene-3a-carboxylate
  参考文献：
  名称：

  Novel 2-aminooctahydrocyclopentalene-3a-carboxamides as potent CCR2 antagonists

  摘要：

  Novel CCR2 antagonists with a novel 2-aminooctahydrocyclopentalene-3a-carboxamide scaffold were designed. SAR studies led to a series of potent compounds. For example, compound 51 had a good PK profile in both dog and monkey, and exhibited excellent efficacy when dosed orally in an inflammation model in hCCR2 KI mice. In addition, an asymmetric synthesis to the core structures was developed. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.10.069

文献信息

• Chiral aminocyclopentene-based cycloaddition strategies to bicyclic [3.3.0] rings
  作者：Chaozhong Cai、Fu-An Kang、Derek A. Beauchamp、Zhihua Sui、Ronald K. Russell、Christopher A. Teleha

  DOI：10.1016/j.tetasy.2013.04.014

  日期：2013.6

  Two cycloaddition methods were applied to chiral protected aminocyclopentenes 2 and 9 and provided novel bicyclic products 3 and 4 in good yields. The explanation for the observed stereochemistry was based on the sterically encumbered beta-face forcing the cycloadditions to occur on the alpha-face of the cyclopentene ring. The stereochemistry of 4 was confirmed by X-ray of the fumarate salt 10 and showed the trans-relationship between the newly formed ring and the chiral -NHBoc group. (C) 2013 Elsevier Ltd. All rights reserved.