N-(1-(4-fluorophenyl)-3-(naphth-2-yl)-3-oxopropyl)acetamide | 1240398-47-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: N-(1-(4-fluorophenyl)-3-(naphth-2-yl)-3-oxopropyl)acetamide
• 英文别名: N-[1-(4-fluorophenyl)-3-naphthalen-2-yl-3-oxopropyl]acetamide
• CAS: 1240398-47-3
• 化学式: C₂₁H₁₈FNO₂
• 分子量: 335.378
• InChiKey: COPNTBUIZWWWFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对氟苯甲醛 、 乙腈 、 2-萘乙酮 在 四氯化硅 、 zinc(II) chloride 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以75%的产率得到N-(1-(4-fluorophenyl)-3-(naphth-2-yl)-3-oxopropyl)acetamide
  参考文献：
  名称：

  Tetrachlorosilane-Zinc Chloride as a New Potent Binary Reagent for One-Pot, Three-Component Synthesis of Mannich-Type Products

  摘要：

  A combination of tetrachlorosilane and zinc chloride in dichloromethane as an efficient and ambient binary reagent to promote a one-pot amidoalkylation reaction of enolizable ketones, aromatic aldehydes with acetonitriles, or benzonitrile have been developed. The newly synthesized beta-acetamidoketones 3 and beta-benzamidoketones 5 were obtained in good yields.

  DOI：

  10.1080/10426500802589907

文献信息

• Tetrachlorosilane-Zinc Chloride as a New Potent Binary Reagent for One-Pot, Three-Component Synthesis of Mannich-Type Products
  作者：Doria S. Badawy、Ebrahim Abdel-Galil、Ezzat M. Kandeel、Wahid M. Basyouni、Tamer K. Khatab

  DOI：10.1080/10426500802589907

  日期：2009.10.30

  A combination of tetrachlorosilane and zinc chloride in dichloromethane as an efficient and ambient binary reagent to promote a one-pot amidoalkylation reaction of enolizable ketones, aromatic aldehydes with acetonitriles, or benzonitrile have been developed. The newly synthesized beta-acetamidoketones 3 and beta-benzamidoketones 5 were obtained in good yields.