N-t-Butyl-oxycarbonylglutamine | 1030004-01-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-t-Butyl-oxycarbonylglutamine
• 英文别名: 2-Amino-5-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoic acid
• CAS: 1030004-01-3
• 化学式: C₁₀H₁₈N₂O₅
• 分子量: 246.263
• InChiKey: TXIQFAIGGLVOTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  119
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-t-Butyl-oxycarbonylglutamine 在 N-甲基吗啉 作用下， 以 四氢呋喃 为溶剂， 生成 Glutaminyl Thiazolidine Hydrochloride
  参考文献：
  名称：

  Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels

  摘要：

  本发明提供了本发明的DPIV抑制剂的新用途，以及其相应的药用可接受的酸盐形式，用于降低血压水平。

  公开号：

  US20030176357A1

文献信息

• Use of dipeptidyl peptidase IV inhibitors
  申请人：——

  公开号：US20030119750A1

  公开（公告）日：2003-06-26

  The present invention provides a new use of DP IV-inhibitors. The compounds of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, are useful in treating conditions mediated by DP IV or DP IV-like enzymes, such as immune, autoimmune or central nervous system disorder selected from the group consisting of strokes, tumors, ischemia, Parkinson's disease and migraines. In a more preferred embodiment, the compounds of the present invention are useful for the treatment of multiple sclerosis.

  本发明提供了DP IV-抑制剂的新用途。本发明的化合物及其相应的药学上可接受的酸盐形式，可用于治疗由DP IV或DP IV类酶介导的疾病，如免疫、自身免疫或中枢神经系统紊乱，包括中风、肿瘤、缺血、帕金森病和偏头痛。在更优选的实施方式中，本发明的化合物可用于治疗多发性硬化症。
• Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
  申请人：von Hoersten Stephan

  公开号：US20050171025A1

  公开（公告）日：2005-08-04

  The present invention provides new uses of DPIV-inhibitors of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, for treating conditions mediated by DPIV or DPIV-like enzymes, such as cancer and tumors. In a more preferred embodiment, the compounds of the present invention are useful for the treatment of metastasis and tumor colonization.

  本发明提供了使用本发明的DPIV抑制剂及其相应的药用酸盐形式治疗由DPIV或DPIV样酶介导的疾病的新用途，如癌症和肿瘤。在更优选的实施方式中，本发明的化合物适用于治疗转移和肿瘤殖民。
• Combination therapy for glycaemic control
  申请人：Demuth Hans-Ulrich

  公开号：US20060287251A1

  公开（公告）日：2006-12-21

  The present invention relates to method of treatment, in particular to a method for the treatment of diabetes mellitus, especially non-insulin dependent diabetes mellitus (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus the predi,betic state and/or obesity and to compositions for use in s ch method.

  本发明涉及治疗方法，特别是一种用于治疗糖尿病的方法，尤其是非胰岛素依赖性糖尿病（NIDDM）或2型糖尿病以及与糖尿病相关的糖尿病前期状态和/或肥胖症的条件，以及用于该种方法的组合物。
• RESIST UNDERLAYER FILM-FORMING COMPOSITION
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20150087155A1

  公开（公告）日：2015-03-26

  A composition forms a resist underlayer film showing improved adhesiveness to a resist pattern. A resist underlayer film-forming composition for lithography, including: a polymer that has a structure of Formula (1a), Formula (1b), or Formula (2) below on an end of the polymer; and an organic solvent: (where R 1 is a hydrogen atom or a methyl group; each of R 2 and R 3 is independently a hydrogen atom or an organic group such as a hydrocarbon group, etc., the hydrocarbon group optionally has at least one of a hydroxy group and a methylthio group as substituent(s); R 4 is a hydrogen atom or a hydroxy group; Q 1 is an arylene group; v is 0 or 1; y is an integer of 1 to 4; w is an integer of 1 to 4; x 1 is 0 or 1; and x 2 is an integer of 1 to 5).

  一种组成物形成抗蚀底层膜，显示出对抗蚀图案改进的粘附性。一种用于光刻的抗蚀底层膜形成组合物，包括：具有以下公式（1a）、公式（1b）或公式（2）结构的聚合物，其位于聚合物的一端；以及有机溶剂：（其中R1是氢原子或甲基基团；R2和R3各自独立地是氢原子或有机基团，例如烃基团等，烃基团可选地具有至少一个羟基和一个甲硫基作为取代基；R4是氢原子或羟基；Q1是芳基烃基团；v为0或1；y为1到4的整数；w为1到4的整数；x1为0或1；x2为1到5的整数）。
• Amide compounds their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0339927A2

  公开（公告）日：1989-11-02

  New amide compounds of the general formula [I]: wherein R is a hydrogen atom or an acyl group, m is an integer of 1 to 3, n is an integer of 1 to 4, p is an integer of 1 or 2, q is an integer of 1 to 6, x is an integer of 2 to 6 and y is an integer of 1 to 3, with the proviso that, when (ii) n is 1, (iii) p is 1, (iv) q is 5 and (v) R is hydrogen atom, [(CH2)x-NH]y is neither (CH2)2NH(CH2)sNH-(CH2)3NH nor (CH2)2NH-(CH2)4NH(CH2)3NH, and salts thereof have excellent glutamate receptor-inhibiting activities, and they can be produced by the following reaction scheme: or wherein the symbols are as defined above except that the hydroxyl, imino or/and amino group or groups may be protected.

  通式[I]的新酰胺化合物： 其中 R 是氢原子或酰基，m 是 1 至 3 的整数，n 是 1 至 4 的整数，p 是 1 或 2 的整数，q 是 1 至 6 的整数，x 是 2 至 6 的整数，y 是 1 至 3 的整数，但条件是，当 (ii)n为1，(iii)p为1，(iv)q为5，(v)R为氢原子时，[(CH2)x-NH]y既不是( )2NH( )sNH-( )3NH，也不是( )2NH-( )4NH( )3NH： 或 其中符号如上定义，但羟基、亚氨基或/和氨基可被保护。