Diethyl 2-but-3-enyl-2-[2-[tert-butyl(dimethyl)silyl]oxyethyl]propanedioate | 497157-33-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Diethyl 2-but-3-enyl-2-[2-[tert-butyl(dimethyl)silyl]oxyethyl]propanedioate
• CAS: 497157-33-2
• 化学式: C₁₉H₃₆O₅Si
• 分子量: 372.577
• InChiKey: VGVGYIJSWSQOCT-UHFFFAOYSA-N

物化性质

• 沸点：
  395.6±42.0 °C(Predicted)
• 密度：
  0.964±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.48
• 重原子数：
  25
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Diethyl 2-but-3-enyl-2-[2-[tert-butyl(dimethyl)silyl]oxyethyl]propanedioate 在 臭氧 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 24.42h， 生成 2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(3-hydroxy-pent-4-enyl)-malonic acid diethyl ester
  参考文献：
  名称：

  SYNTHESIS OF DIASTEREOMERICALLY ENRICHED CYCLIC HOMOALLYLIC ALCOHOLS USING MOLYBDENUM π-ALLYL COMPLEXES

  摘要：

  Condensation of CpMo(NO)(pi-allyl)I complexes bearing a tethered aldehyde gave cyclic homoallylic alcohols with a varying degree of diastereoselectivity. Cyclohexyl and tetrahydronaphthyl derivatives were prepared in moderate to good yields. The diastereoselectivity is highly dependent on the substituents on the ring.

  DOI：

  10.1081/scc-120006039
• 作为产物：
  描述：

  （2-溴乙氧基）-特丁基二甲基硅烷 在 sodium hydride 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 28.25h， 生成 Diethyl 2-but-3-enyl-2-[2-[tert-butyl(dimethyl)silyl]oxyethyl]propanedioate
  参考文献：
  名称：

  SYNTHESIS OF DIASTEREOMERICALLY ENRICHED CYCLIC HOMOALLYLIC ALCOHOLS USING MOLYBDENUM π-ALLYL COMPLEXES

  摘要：

  Condensation of CpMo(NO)(pi-allyl)I complexes bearing a tethered aldehyde gave cyclic homoallylic alcohols with a varying degree of diastereoselectivity. Cyclohexyl and tetrahydronaphthyl derivatives were prepared in moderate to good yields. The diastereoselectivity is highly dependent on the substituents on the ring.

  DOI：

  10.1081/scc-120006039

文献信息

• SYNTHESIS OF DIASTEREOMERICALLY ENRICHED CYCLIC HOMOALLYLIC ALCOHOLS USING MOLYBDENUM π-ALLYL COMPLEXES
  作者：Marie E. Krafft、Peter Schmidt

  DOI：10.1081/scc-120006039

  日期：2002.1

  Condensation of CpMo(NO)(pi-allyl)I complexes bearing a tethered aldehyde gave cyclic homoallylic alcohols with a varying degree of diastereoselectivity. Cyclohexyl and tetrahydronaphthyl derivatives were prepared in moderate to good yields. The diastereoselectivity is highly dependent on the substituents on the ring.