2-amino-4-(furan-2-yl) thiazole-5-carbonitrile | 1139743-07-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-amino-4-(furan-2-yl) thiazole-5-carbonitrile
• 英文别名: 2-Amino-4-(furan-2-yl)-1,3-thiazole-5-carbonitrile
• CAS: 1139743-07-9
• 化学式: C₈H₅N₃OS
• 分子量: 191.213
• InChiKey: VABLCRXGYWXHRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  104
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] NEW COMPOUNDS AS ADENOSINE A1 RECEPTOR ANTAGONISTS<br/>[FR] NOUVEAUX COMPOSÉS COMME ANTAGONISTES DES RÉCEPTEURS A1 DE L'ADÉNOSINE
  申请人：PALOBIOFARMA SL

  公开号：WO2009044250A1

  公开（公告）日：2009-04-09

  This compounds correspond to the formula (I), where: R1 represents and aryl or heteroaryl group optionally substituted by one or more substituents selected from the group consisting of halogen atoms, straight or branched optionally substituted lower alkyl, cycloalkyl, hydroxy, straight or branched, optionally substituted lower alkoxy, cyano, or -CO2R', wherein R' represents a hydrogen atom or a straight or branched, optionally substituted lower alkyl group; R2 represents a group selected from: a) a straight or branched lower alkyl group substituted by one or more carboxylic groups (-COOH) and optionally substituted by one or more halogen atoms; b) a cycloalkyl group substituted by one or more carboxylic groups (-COOH) and optionally substituted by one or more halogen atoms; c) a straight or branched alkylcycloalkyl or cycloalkylalkyl group substituted by one or more carboxylic groups (-COOH) and optionally substituted by one or more halogen atoms. Formula (I).

  这些化合物对应于公式(I)，其中：R1代表芳基或杂环基，可选择地被一个或多个取代基所取代，所述取代基从卤素原子、直链或支链的可选择取代的低烷基、环烷基、羟基、直链或支链的可选择取代的低烷氧基、氰基或-CO2R'中选择，其中R'代表氢原子或直链或支链的可选择取代的低烷基；R2代表从以下选组中选择的基团：a）被一个或多个羧基（-COOH）取代的直链或支链低烷基，可选择地被一个或多个卤素原子取代；b）被一个或多个羧基（-COOH）取代的环烷基，可选择地被一个或多个卤素原子取代；c）被一个或多个羧基（-COOH）取代的直链或支链烷基环烷基或环烷基烷基，可选择地被一个或多个卤素原子取代。公式（I）。
• NEW COMPOUNDS AS ADENOSINE A1 RECEPTOR ANTAGONISTS
  申请人：Gonzalez Lio Lyhen

  公开号：US20100311703A1

  公开（公告）日：2010-12-09

  This compounds correspond to the formula (I), where: R 1 represents and aryl or heteroaryl group optionally substituted by one or more substituents selected from the group consisting of halogen atoms, straight or branched optionally substituted lower alkyl, cycloalkyl, hydroxy, straight or branched, optionally substituted lower alkoxy, cyano, or —CO 2 R′, wherein R′ represents a hydrogen atom or a straight or branched, optionally substituted lower alkyl group; R 2 represents a group selected from: a) a straight or branched lower alkyl group substituted by one or more carboxylic groups (—COOH) and optionally substituted by one or more halogen atoms; b) a cycloalkyl group substituted by one or more carboxylic groups (—COOH) and optionally substituted by one or more halogen atoms; c) a straight or branched alkylcycloalkyl or cycloalkylalkyl group substituted by one or more carboxylic groups (—COOH) and optionally substituted by one or more halogen atoms. Formula (I).

  这些化合物对应于公式(I)，其中: R1代表芳基或杂环芳基，可选地被来自卤素原子、直链或支链、可选地被取代的低烷基、环烷基、羟基、直链或支链、可选地被取代的低烷氧基、氰基或-CO2R'中的一种或多种取代基所取代，其中R'代表氢原子或直链或支链、可选地被取代的低烷基; R2代表以下之一的基团: a)一个直链或支链的低烷基，其被一个或多个羧基(-COOH)取代，并可选地被一个或多个卤素原子取代; b)一个被一个或多个羧基(-COOH)取代，并可选地被一个或多个卤素原子取代的环烷基; c)一个被一个或多个羧基(-COOH)取代，并可选地被一个或多个卤素原子取代的直链或支链烷基环烷基或环烷基烷基。公式(I)。
• Modulators of the adenosine A3 receptors
  申请人：PALOBIOFARMA, S.L.

  公开号：US10238637B2

  公开（公告）日：2019-03-26

  Modulators of adenosin A3 receptors of formula (I): And procedure for preparing these compounds. Other objectives of the present invention are to provide pharmaceutical compositions comprising an effective amount of these compounds and the use of the compounds for manufacturing a medicament for the treatment of pathological conditions or diseases that can improve by modulation of the adenosine A3 receptor.

  式 (I) 的腺苷 A3 受体调节剂： 以及制备这些化合物的程序。本发明的其他目的是提供包含有效量这些化合物的药物组合物，以及使用这些化合物制造治疗病理状况或疾病的药物，这些病理状况或疾病可通过调节腺苷 A3 受体得到改善。
• Adenosine A3 receptor modulators
  申请人：Palobiofarma, S.L.

  公开号：US10744125B2

  公开（公告）日：2020-08-18

  Modulators of the adenosine A3 receptors of formula (I): and process for preparing said compounds. Other aspects of the present invention are pharmaceutical compositions comprising an effective amount of said compounds and the use of said compounds in the preparation of a medicament for treating pathological conditions or diseases that can be improved by modulation of adenosine A3 receptors.

  式 (I) 的腺苷 A3 受体调节剂： 以及制备所述化合物的工艺。本发明的其他方面是包含有效量所述化合物的药物组合物，以及所述化合物在制备用于治疗可通过调节腺苷 A3 受体得到改善的病理状况或疾病的药物中的用途。
• THIAZOLE MODULATORS OF A3 ADENOSINE RECEPTORS
  申请人：PALOBIOFARMA S.L.

  公开号：EP3248964B1

  公开（公告）日：2019-07-17