[Zn(2,2'-dimethyl-4,4'-bithiazole)I2] | 1390630-36-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [Zn(2,2'-dimethyl-4,4'-bithiazole)I2]
• 英文别名: [Zn(dm4bt)I2]
• CAS: 1390630-36-0
• 化学式: C₈H₈I₂N₂S₂Zn
• 分子量: 515.496
• InChiKey: CZMMGENJMNYZRI-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  2,2'-dimethyl-4,4'-bithiazole 、 zinc(II) iodide 以 甲醇 、 水 、 乙腈 为溶剂， 以72%的产率得到[Zn(2,2'-dimethyl-4,4'-bithiazole)I2]
  参考文献：
  名称：

  Novel mononuclear zinc complexes with 2,2′-dimethyl-4,4′-bithiazole: Synthesis, crystal structure and DNA-binding studies

  摘要：

  Two neutral mononuclear zinc complexes with 2,2'-dimethyl-4,4'-bithiazole (dm4bt), [Zn(dm4bt)Br-2] (1) and [Zn(dm4bt)I-2] (2) were synthesized and characterized by elemental analysis, IR, UV-Vis and NMR spectroscopy and their structures were studied by single-crystal diffraction. These complexes have a bidentate nitrogenous ligand with two halide anions attached to a zinc metal in a distorted tetrahedral geometry. The interaction ability of the two complexes with native calf thymus DNA (CT-DNA) has been monitored as a function of the metal complex-DNA molar ratio by UV-Vis absorption spectrophotometry, fluorescence spectroscopy, circular dichroism (CD) and thermal denaturation studies. The intrinsic binding constants K-b of complexes 1 and 2, with CT-DNA obtained from UV-Vis absorption studies were 3.47 +/- 0.02 x 10(4) M-1 and 3.19 +/- 0.02 x 10(4) M-1, respectively. Both complexes exhibit luminescent properties in the absence and presence of CT-DNA and the fluorescence study ascertain the interaction of 1 and 2 with CT-DNA. Moreover the addition of the complexes to CT-DNA (1:2) led to an increase of the melting temperature of DNA up to around 2.7 degrees C. Further fluorimetric studies were performed using methylene blue (MB) as a fluorescence probe, indicating low intercalative interaction of the complexes with CT-DNA. The CD study also points to groove binding mode in the complexes rather than intercalation mode. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.05.006