N,N-diethyl-glycine 4-phenyl-thiazol-2-ylamide | 5039-17-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-diethyl-glycine 4-phenyl-thiazol-2-ylamide
• 英文别名: N,N-diethyl-glycine-(4-phenyl-thiazol-2-ylamide)；N,N-Diaethyl-glycin-(4-phenyl-thiazol-2-ylamid)；2-Diaethylaminoacetylamino-4-phenyl-thiazol；2-Diethylaminoacetamido-4-phenylthiazol；Diethylaminoacetyl-4-phenylthiazol；2-(diethylazaniumyl)-N-(4-phenyl-1,3-thiazol-2-yl)ethanimidate
• CAS: 5039-17-8
• 化学式: C₁₅H₁₉N₃OS
• 分子量: 289.401
• InChiKey: DGGZBMFESMPPMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  73.5
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2934100090

反应信息

• 作为产物：
  描述：

  2-氨基-4-苯基噻唑 在 吡啶 、 苯 作用下， 生成 N,N-diethyl-glycine 4-phenyl-thiazol-2-ylamide
  参考文献：
  名称：

  Sridhar; Narang, Journal of the Indian Chemical Society, 1954, vol. 31, p. 495,497

  摘要：

  DOI：

文献信息

• Tetu,O. et al., Bulletin de la Societe Chimique de France, 1966, p. 342 - 345
  作者：Tetu,O. et al.

  DOI：——

  日期：——
• Bhargava,P.N.; Ram,P., Journal of the Indian Chemical Society, 1961, vol. 38, p. 167 - 168
  作者：Bhargava,P.N.、Ram,P.

  DOI：——

  日期：——
• Sridhar; Narang, Journal of the Indian Chemical Society, 1954, vol. 31, p. 495,497
  作者：Sridhar、Narang

  DOI：——

  日期：——
• SRIVASTAVA P. K.; SHARMA R. D.; RAI S. K., ACTA CHIM. ACAD. SCI. HUNG., 1977, 94, NO 3, 229-232
  作者：SRIVASTAVA P. K.、 SHARMA R. D.、 RAI S. K.

  DOI：——

  日期：——
• Synthesis of 2-(aminoacetylamino)thiazole derivatives and comparison of their local anaesthetic activity by the method of action potential
  作者：A Geronikaki、G Theophilidis

  DOI：10.1016/0223-5234(92)90091-e

  日期：1992.10

  Some numbers of the family of 2-(aminoacetylamino)thiazoles were synthesized. The structure of these compounds was identified both by elemental as well as by spectroscopic analysis (UV, IR, H-NMR, MS). The possible local anaesthetic action of these compounds was also tested using the sciatic nerve of the frog. None of the tested compounds were found to have local anaesthetic action in on in vitro preparations as lidocaine, but one of the compounds showed a similar anaesthetic action to procaine.