peristrophine acetate | 1385013-49-9

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: peristrophine acetate
• CAS: 1385013-49-9
• 化学式: C₁₆H₁₄N₂O₅
• 分子量: 314.298
• InChiKey: ITRTWBNEHKCWOM-UHFFFAOYSA-N

物化性质

• 沸点：
  551.5±50.0 °C(predicted)
• 密度：
  1.39±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  2-amino-7,8-dimethoxy-3H-phenoxazine-3-one 、 乙酸酐 在 吡啶 作用下， 以72%的产率得到peristrophine acetate
  参考文献：
  名称：

  Isolation, characterisation and biological evaluation of a phenoxazine, a natural dyestuff isolated from leaves ofPeristrophe bivalvis

  摘要：

  Peristrophe bivalvis (L.) Merr. (Acanthaceae) is a wild growing and cultivated plant used for dyeing of foods by the ethnic minorities of Vietnam. The major component of the colour aqueous extract (CAE) of its leaves was identified as peristrophine by spectral analysis, especially the 2D NMR spectra (HSQC, HMBC and NOESY). Considering the widespread utilisation of the decoction of this plant for food dyeing, we evaluated the acute oral toxicity of the CAE. Based on the results in an acute toxicity study in mice, the LD50 value of the CAE was determined as 9100 +/- 290mgkg(1) body weight. Additionally, invitro cytotoxic assay showed an inhibition of peristrophine against Hepatocellular carcinoma (HepG2, IC(50)3.90 mu gmL(1)). CAE and peristrophine (1) have also been tested for their ability to affect the cell number of the OCI acute myeloid leukaemia cell line. CAE and peristrophine significantly decreased the OCI cell number at different concentrations and times of treatment.

  DOI：

  10.1080/14786419.2012.698409