(1R,2R)-ethyl 2-((R)-1-phenylethylamino)cyclopentanecarboxylate | 163877-11-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (1R,2R)-ethyl 2-((R)-1-phenylethylamino)cyclopentanecarboxylate
• 英文别名: ethyl (1R,2R)-2-[[(1R)-1-phenylethyl]amino]cyclopentane-1-carboxylate
• CAS: 163877-11-0
• 化学式: C₁₆H₂₃NO₂
• 分子量: 261.364
• InChiKey: XFESHQNKLZLTHP-BPLDGKMQSA-N

物化性质

• 沸点：
  352.9±35.0 °C(Predicted)
• 密度：
  1.05±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1R,2R)-ethyl 2-((R)-1-phenylethylamino)cyclopentanecarboxylate 在 palladium on activated charcoal lithium hydroxide 、 氢气 作用下， 生成 (1R,2R)-(-)-2-氨基-1-环戊烷羧酸
  参考文献：
  名称：

  (S,S)-trans-Cyclopentane-Constrained Peptide Nucleic Acids. A General Backbone Modification that Improves Binding Affinity and Sequence Specificity

  摘要：

  Replacing the ethylenediamine portion of aminoethylglycine peptide nucleic acids (aegPNAs) with one or more (S,S)-trans-cyclopentane diamine units significantly increases binding affinity and sequence specificity to complementary DNA, making these modified PNAs ideal for use as nucleic acid probes in genomic analysis. The synthesis and study of this new class of PNAs (tcypPNAs) is described in which trans-cyclopentane diamine has been incorporated into several positions, and in varying number, within PNA backbones of mixed-base sequences.

  DOI：

  10.1021/ja046280q
• 作为产物：
  描述：

  2-氧代环戊羧酸乙酯 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 (1R,2R)-ethyl 2-((R)-1-phenylethylamino)cyclopentanecarboxylate
  参考文献：
  名称：

  (S,S)-trans-Cyclopentane-Constrained Peptide Nucleic Acids. A General Backbone Modification that Improves Binding Affinity and Sequence Specificity

  摘要：

  Replacing the ethylenediamine portion of aminoethylglycine peptide nucleic acids (aegPNAs) with one or more (S,S)-trans-cyclopentane diamine units significantly increases binding affinity and sequence specificity to complementary DNA, making these modified PNAs ideal for use as nucleic acid probes in genomic analysis. The synthesis and study of this new class of PNAs (tcypPNAs) is described in which trans-cyclopentane diamine has been incorporated into several positions, and in varying number, within PNA backbones of mixed-base sequences.

  DOI：

  10.1021/ja046280q

文献信息

• Cycloalkyl Substituted Pyrimidinediamine Compounds And Their Uses
  申请人：Li Hui

  公开号：US20080009494A1

  公开（公告）日：2008-01-10

  The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.

  本公开提供具有抗增殖活性的2,4-嘧啶二胺化合物，包含该化合物的组合物以及使用该化合物抑制细胞增殖和治疗增殖性疾病（如肿瘤性癌症）的方法。
• US7858633B2
  申请人：——

  公开号：US7858633B2

  公开（公告）日：2010-12-28
• (<i>S</i>,<i>S</i>)-<i>trans-</i>Cyclopentane-Constrained Peptide Nucleic Acids. A General Backbone Modification that Improves Binding Affinity and Sequence Specificity
  作者：Jonathan K. Pokorski、Mark A. Witschi、Bethany L. Purnell、Daniel H. Appella

  DOI：10.1021/ja046280q

  日期：2004.11.1

  Replacing the ethylenediamine portion of aminoethylglycine peptide nucleic acids (aegPNAs) with one or more (S,S)-trans-cyclopentane diamine units significantly increases binding affinity and sequence specificity to complementary DNA, making these modified PNAs ideal for use as nucleic acid probes in genomic analysis. The synthesis and study of this new class of PNAs (tcypPNAs) is described in which trans-cyclopentane diamine has been incorporated into several positions, and in varying number, within PNA backbones of mixed-base sequences.