2-amino-2-(5-(5-(4-butoxy-3-chlorophenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol | 1608144-37-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-amino-2-(5-(5-(4-butoxy-3-chlorophenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol
• 英文别名: 2-Amino-2-[5-[5-(4-butoxy-3-chlorophenyl)-1,2,4-oxadiazol-3-yl]-1-benzofuran-2-yl]propane-1,3-diol
• CAS: 1608144-37-1
• 化学式: C₂₃H₂₄ClN₃O₅
• 分子量: 457.914
• InChiKey: HQLPQUFUIFCXRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  128
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• [EN] ORGANIC COMPOUNDS<br/>[FR] COMPOSÉS ORGANIQUES
  申请人：AKAAL PHARMA PTY LTD

  公开号：WO2014063199A1

  公开（公告）日：2014-05-01

  Novel benzofuran derivatives are disclosed. The derivatives have S1P1 receptor activity and/or disease modifying activity and find use in the treatment of conditions or diseases associated with the immune, vascular and nervous systems in animals and/or humans

  揭示了新型苯并呋喃衍生物。这些衍生物具有S1P1受体活性和/或疾病修饰活性，并可用于治疗与动物和/或人类的免疫、血管和神经系统相关的疾病或症状。
• [EN] COMPOSITIONS COMPRISING S1P RECEPTOR MODULATORS<br/>[FR] COMPOSITIONS COMPRENANT DES MODULATEURS DE RÉCEPTEURS DE S1P
  申请人：AKAAL PHARMA PTY LTD

  公开号：WO2017024355A1

  公开（公告）日：2017-02-16

  Compositions comprising S1 P receptor modulators and at least one compound selected from one or more of the group consisting of steroids, opioids and non-steroidal anti-inflammatory drugs are provided. The compositions find use in the treatment of disease, particularly inflammation and immune mediated disorders.