4-(4-(4-ethylphenyl)oxazol-5-yl)-6-isopropylbenzene-1,3-diol | 1155371-14-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(4-(4-ethylphenyl)oxazol-5-yl)-6-isopropylbenzene-1,3-diol
• 英文别名: 4-[4-(4-Ethylphenyl)-1,3-oxazol-5-yl]-6-propan-2-ylbenzene-1,3-diol
• CAS: 1155371-14-4
• 化学式: C₂₀H₂₁NO₃
• 分子量: 323.392
• InChiKey: QSJKPMIWDYHOOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  66.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE<br/>[FR] COMPOSÉS 6-ISOPROPYL-BENZÈNE-1,3-DIOLS SUBSTITUÉS EN POSITION 4 ET LEUR UTILISATION
  申请人：TOPOTARGET AS

  公开号：WO2009066060A2

  公开（公告）日：2009-05-28

  The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 4-substituted-6-isopropyl-benzene 1,3-diol compounds (referred to herein as IBD compounds), which, inter alia, inhibit heat shock protein 90 (HSP90) function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HSP90 function, and in the treatment of diseases and conditions that are mediated by HSP90, that are ameliorated by the inhibition of HSP90 function, etc., including proliferative conditions such as cancer, etc.