(3R,4S)-4-Dibenzylamino-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-methyl-hex-1-yn-3-ol | 847983-96-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3R,4S)-4-Dibenzylamino-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-methyl-hex-1-yn-3-ol
• CAS: 847983-96-4
• 化学式: C₂₆H₃₃NO₃
• 分子量: 407.553
• InChiKey: MARRRARBCYUTEU-GVAUOCQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.23
• 重原子数：
  30.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  41.93
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (3R,4S)-4-Dibenzylamino-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-methyl-hex-1-yn-3-ol 在 palladium dihydroxide 吡啶 、 camphor-10-sulfonic acid 、 氢气 、 potassium carbonate 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 [(S)-1-((2R,5R)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-2-methyl-propyl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis of C6-substituted 3,4-dideoxy furanoid sugar amino acids

  摘要：

  A variety of chiral 3,4-dideoxy furanoid sugar amino acids have been synthesized, which were substituted at C6 with different alkyl groups, such as methyl, benzyl, isopropyl and hydroxymethyl synthesized from their corresponding N,N-dibenzy-laminoaldehydes. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.11.058
• 作为产物：
  描述：

  (4S)-4-(2,2-dibromoethenyl)-2,2-dimethyl-1,3-dioxolane 、 L-dibenzylvalinal 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 生成 (3R,4S)-4-Dibenzylamino-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-methyl-hex-1-yn-3-ol
  参考文献：
  名称：

  Synthesis of C6-substituted 3,4-dideoxy furanoid sugar amino acids

  摘要：

  A variety of chiral 3,4-dideoxy furanoid sugar amino acids have been synthesized, which were substituted at C6 with different alkyl groups, such as methyl, benzyl, isopropyl and hydroxymethyl synthesized from their corresponding N,N-dibenzy-laminoaldehydes. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.11.058