trans-2,4-Dihydroxy-4'-methoxychalkon | 476487-21-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: trans-2,4-Dihydroxy-4'-methoxychalkon
• 英文别名: 2',4'-dihydroxy-4-methoxychalcone；2',6'-Dihydroxy-4-methoxychalcone；2,4-dihydroxy-4'-methoxychalcone；(E)-3-(2,4-dihydroxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
• CAS: 476487-21-5
• 化学式: C₁₆H₁₄O₄
• 分子量: 270.285
• InChiKey: SSIIMXFVLRNTNY-WEVVVXLNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  trans-2,4-Dihydroxy-4'-methoxychalkon 以 水 为溶剂， 生成 7-Hydroxy-4'-methoxyflavyliumperchlorat
  参考文献：
  名称：

  Fanghaenel, E.; Willscher, S.; Ortmann, W., Journal fuer Praktische Chemie (Leipzig), 1989, vol. 331, # 2, p. 195 - 206

  摘要：

  DOI：
• 作为产物：
  描述：

  7-Hydroxy-4'-methoxyflavyliumperchlorat 在 水 作用下， 生成 trans-2,4-Dihydroxy-4'-methoxychalkon
  参考文献：
  名称：

  Fanghaenel, E.; Willscher, S.; Ortmann, W., Journal fuer Praktische Chemie (Leipzig), 1989, vol. 331, # 2, p. 195 - 206

  摘要：

  DOI：

文献信息

• Cosmetic composition containing hydroxylated chalcone derivatives and
  申请人：L'Oreal

  公开号：US04867964A1

  公开（公告）日：1989-09-19

  Cosmetic composition containing hydroxylated chalcone derivatives and its use for protecting the skin and the hair against luminous radiations, new hydroxylated chalcone derivatives employed and process for their preparation. The invention relates to a cosmetic composition for protecting the skin and the hair against UV rays comprising, in a cosmetically acceptable substrate, at least one derivative of 2-hydroxychalcone of formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 denote, independently of each other, a hydrogen atom, a straight- or branched-chain C.sub.1 -C.sub.12 alkyl group, a straight- or branched-chain C.sub.1 -C.sub.12 alkyl group or a straight- or branched-chain C.sub.2 -C.sub.20 acyloxy group. The invention also relates to new derivatives of 2-hydroxychalcone and the process for their preparation.

  含有羟基茚酮衍生物的化妆品组合物及其用途，用于保护皮肤和头发免受光辐射，采用新的羟基茚酮衍生物并制备它们的过程。该发明涉及一种用于保护皮肤和头发免受紫外线辐射的化妆品组合物，包括至少一种2-羟基茚酮衍生物，其化学式为：##STR1## 其中R.sub.1、R.sub.2、R.sub.3和R.sub.4分别独立表示氢原子、直链或支链C.sub.1 -C.sub.12烷基、直链或支链C.sub.1 -C.sub.12烷基或直链或支链C.sub.2 -C.sub.20酰氧基。该发明还涉及新的2-羟基茚酮衍生物及其制备过程。
• Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
  申请人：Wong C.W. Norman

  公开号：US20060205792A1

  公开（公告）日：2006-09-14

  The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.

  本公开提供了一些非天然的多酚化合物，这些化合物可以上调载脂蛋白A-I（ApoA-I）的表达。所述的组合物和方法可用于治疗和预防心血管疾病及相关疾病状态，包括胆固醇或脂质相关紊乱，例如动脉粥样硬化。
• Stilbenes and Chalcones for the Prevention and Treatment of Cardiovascular Diseases
  申请人：Wong Norman C.W.

  公开号：US20110082176A1

  公开（公告）日：2011-04-07

  The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.

  本公开提供非自然产生的多酚化合物，可以上调载脂蛋白A-I（ApoA-I）的表达。所披露的组合物和方法可用于治疗和预防心血管疾病和相关疾病状态，包括胆固醇或脂质相关的疾病，例如动脉粥样硬化。
• US4867964A
  申请人：——

  公开号：US4867964A

  公开（公告）日：1989-09-19
• US7846915B2
  申请人：——

  公开号：US7846915B2

  公开（公告）日：2010-12-07