N-{3-[4-(2-aminopyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl]-2,4-difluorophenyl}-N-[(2,5-difluorophenyl)sulfonyl]acetamide | 1321536-98-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-{3-[4-(2-aminopyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl]-2,4-difluorophenyl}-N-[(2,5-difluorophenyl)sulfonyl]acetamide
• 英文别名: N-[3-[4-(2-aminopyridin-4-yl)-1-ethylpyrazol-3-yl]-2,4-difluorophenyl]-N-(2,5-difluorophenyl)sulfonylacetamide
• CAS: 1321536-98-4
• 化学式: C₂₄H₁₉F₄N₅O₃S
• 分子量: 533.506
• InChiKey: LNFUSZCPKLOMOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  120
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• [EN] SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS<br/>[FR] DÉRIVÉS SULFONAMIDO DES 3,4-DIARYLPYRAZONES COMME INHIBITEURS DES PROTÉINES KINASES
  申请人：NERVIANO MEDICAL SCIENCES SRL

  公开号：WO2011092088A1

  公开（公告）日：2011-08-04

  Compounds which are sulfonamido 3,4-diarylpyrazole derivatives, or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is their use as prodrugs.

  揭示了磺胺基3,4-二芳基吡唑衍生物或其药用可接受盐、其制备过程以及包括它们的药物组合物；这些化合物在治疗由改变的蛋白激酶活性引起和/或与之相关的疾病方面具有用处，如癌症、病毒感染、预防HIV感染者中艾滋病发展、细胞增殖紊乱、自身免疫和神经退行性疾病；还揭示了它们作为前药的用途。
• SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS
  申请人：Nerviano Medical Sciences S.r.l.

  公开号：EP2528909A1

  公开（公告）日：2012-12-05
• US8791265B2
  申请人：——

  公开号：US8791265B2

  公开（公告）日：2014-07-29