2-hydroxy-3-[5-(2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid | 1032614-77-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-hydroxy-3-[5-(2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid
• 英文别名: 2-Hydroxy-3-[5-(2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]benzoic acid
• CAS: 1032614-77-9
• 化学式: C₁₆H₁₂N₂O₅
• 分子量: 312.282
• InChiKey: HTUXBRHZCQVZKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, composistions thereof and the use for nonsense suppression
  申请人：Almstead Neil G.

  公开号：US20080139632A1

  公开（公告）日：2008-06-12

  Novel hydroxylated 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising a hydroxylated 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.

  本发明公开了一种新型的羟基化1,2,4-噁二唑苯甲酸衍生物化合物，以及使用该羟基化1,2,4-噁二唑苯甲酸衍生物的方法和包含该化合物的药物组合物。该方法包括治疗或预防通过调节过早翻译终止或无意义介导的mRNA降解而改善的疾病，或改善与之相关的一个或多个症状的方法。
• HYDROXYLATED 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS, COMPOSITIONS THEREOF AND THEIR USE IN BIOASSAYS
  申请人：Almstead Neil G.

  公开号：US20120087896A1

  公开（公告）日：2012-04-12

  Novel hydroxylated 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising a hydroxylated 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
• US8101641B2
  申请人：——

  公开号：US8101641B2

  公开（公告）日：2012-01-24
• US8691511B2
  申请人：——

  公开号：US8691511B2

  公开（公告）日：2014-04-08
• [EN] HYDROXYLATED 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS, COMPOSITIONS THEREOF AND THE USE FOR NONSENSE SUPPRESSION<br/>[FR] COMPOSÉS D'ACIDE 1,2,4-OXADIOZOLE BENZOÏQUE HYDROXYLÉ,LEURS COMPOSITIONS ET LEUR UTILISATION POUR UNE SUPPRESSION NON-SENS
  申请人：PTC THERAPEUTICS INC

  公开号：WO2008130370A1

  公开（公告）日：2008-10-30

  [EN] Novel hydroxylated 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising a hydroxylated 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
  [FR] La présente invention concerne des composés d'acide 1,2,4-oxadiazole benzoïque hydroxylé, les procédés d'utilisation et des compositions pharmaceutiques comprenant un dérivé d'acide 1,2,4-oxadiazole benzoïque hydroxylé. Les procédés comprennent des meilleurs procédés de traitement ou de prévention d'une maladie par la modulation de la terminaison prématurée de la traduction ou une dégradation de l'ARNm par non-sens, ou l'amélioration d'un ou plusieurs symptômes qui leur sont associés.