2-[(6S)-5-azaspiro[2.4]heptan-6-yl]-6-[2-[4-[2-[(6S)-5-azaspiro[2.4]heptan-6-yl]-1H-imidazol-5-yl]phenyl]ethynyl]-1H-benzimidazole | 1431361-64-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[(6S)-5-azaspiro[2.4]heptan-6-yl]-6-[2-[4-[2-[(6S)-5-azaspiro[2.4]heptan-6-yl]-1H-imidazol-5-yl]phenyl]ethynyl]-1H-benzimidazole
• CAS: 1431361-64-6
• 化学式: C₃₀H₃₀N₆
• 分子量: 474.608
• InChiKey: VDGJCBZWJWNBAS-DQEYMECFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  81.4
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• PROCESSES FOR THE PREPARATION OF NOVEL BENZIMIDAZOLE DERIVATIVES
  申请人：ENANTA PHARMACEUTICALS, INC.

  公开号：US20140316143A1

  公开（公告）日：2014-10-23

  The present invention relates to processes and intermediates for the preparation of novel benzimidazole derivatives, especially in the synthesis of hepatitis C virus NS5A inhibitors. In particular, the present invention relates to processes and intermediates for the preparation of compounds of formulae (I-a):

  本发明涉及制备新型苯并咪唑衍生物的方法和中间体，尤其是在合成丙型肝炎病毒NS5A抑制剂方面。特别是，本发明涉及制备式（I-a）化合物的方法和中间体：
• US8921573B2
  申请人：——

  公开号：US8921573B2

  公开（公告）日：2014-12-30
• [EN] PROCESSES FOR THE PREPARATION OF NOVEL BENZIMIDAZOLE DERIVATIVES<br/>[FR] PROCÉDÉS DE PRÉPARATION DE NOUVEAUX DÉRIVÉS DE BENZIMIDAZOLE
  申请人：ENANTA PHARM INC

  公开号：WO2013059281A2

  公开（公告）日：2013-04-25

  The present invention relates to processes and intermediates for the preparation of novel benzimidazole derivatives, especially in the synthesis of hepatits C virus NS5A inhibitors. In particular, the present invention relates to processes and intermediates for the preparation of compounds of formulae (I-a):