(S)-2-(3-benzyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)-N-cyclohexylacetamide | 1414359-63-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: (S)-2-(3-benzyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)-N-cyclohexylacetamide
• 英文别名: 2-[(3S)-3-benzyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl]-N-cyclohexylacetamide
• CAS: 1414359-63-9
• 化学式: C₃₀H₃₁N₃O₂
• 分子量: 465.595
• InChiKey: DTAORKNQTYHODD-SANMLTNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  61.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Boc-Phe-N(Ph(2-Bz))Gly-NHcHex 在 三氟乙酸 作用下， 以 1,2-二氯乙烷 为溶剂， 以66 mg的产率得到(S)-2-(3-benzyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)-N-cyclohexylacetamide
  参考文献：
  名称：

  Multicomponent Synthesis of Diverse 1,4-Benzodiazepine Scaffolds

  摘要：

  The 1,4-benzodiazepine (BDZ) scaffold is of particular interest in drug design due to a balanced ensemble of beneficial physicochemical properties including a semirigid and compact diazepine ring with spatial placements of several substituents, combined with low number of rotatable bonds, hydrogen bond donors and acceptors, and intermediate lipophilicity. As an alternative to traditional multistep sequential syntheses, we designed routes employing one-pot MCRs to accelerate access diverse BDZ scaffolds in two or three steps.

  DOI：

  10.1021/ol302837h

文献信息

• Integrated Ugi-Based Assembly of Functionally, Skeletally, and Stereochemically Diverse 1,4-Benzodiazepin-2-ones
  作者：Jhonny Azuaje、José M. Pérez-Rubio、Vicente Yaziji、Abdelaziz El Maatougui、José Carlos González-Gomez、Vı́ctor M. Sánchez-Pedregal、Armando Navarro-Vázquez、Christian F. Masaguer、Marta Teijeira、Eddy Sotelo

  DOI：10.1021/jo502382q

  日期：2015.2.6

  A practical, integrated and versatile U-4CR-based assembly of 1,4-benzodiazepin-2-ones exhibiting functionally, skeletally, and stereochemically diverse substitution patterns is described. By virtue of its convergence, atom economy, and bond-forming efficiency, the methodology documented herein exemplifies the reconciliation of structural complexity and experimental simplicity in the context of medicinal chemistry projects.