2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-5-yl}ethanol | 496062-58-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-5-yl}ethanol
• 英文别名: 4-Methyl-2-[4-(trifluoromethyl)phenyl]-5-oxazoleethanol；2-[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-5-yl]ethanol
• CAS: 496062-58-9
• 化学式: C₁₃H₁₂F₃NO₂
• 分子量: 271.239
• InChiKey: LRFBWKIDOIUROR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
  申请人：——

  公开号：US20030216391A1

  公开（公告）日：2003-11-20

  This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

  这项发明涉及新颖的茚基乙酸衍生物，可用于治疗糖尿病、肥胖症、高脂血症和动脉粥样硬化等疾病。该发明还涉及用于制备茚基乙酸衍生物的中间体以及制备方法。
• METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE
  申请人：T3D Therapeutics, Inc.

  公开号：US20180153859A1

  公开（公告）日：2018-06-07

  The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders based on the ApoE4 genotype of human subjects.

  本发明提供了关于人类主体的ApoE4基因型的吲哌乙酸及其衍生物的治疗和/或预防认知障碍的方法。
• [EN] HETEROCYCLIC COMPOUNDS AS MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS, USEFUL FOR THE TREATMENT AND/OR PREVENTION OF DISORDERS MODULATED BY A PPAR<br/>[FR] COMPOSES HETEROCYCLIQUES UTILISES COMME MODULATEURS DES RECEPTEURS ACTIVES PROLIFERATEURS DU PEROXYSOME (PPAR), UTILES DANS LE TRAITEMENT ET/OU LA PREVENTION DE TROUBLES MODULES PAR UN PPAR
  申请人：LILLY CO ELI

  公开号：WO2005051945A1

  公开（公告）日：2005-06-09

  The present invention is directed to a compound of formula (I), or a pharmaceutically acceptable salt, solvate, hydrate or stereoisomer thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.

  本发明涉及一种式(I)的化合物，或其药学上可接受的盐、溶剂合物、水合物或立体异构体，该化合物在治疗或预防由过氧化物酶体增殖激活受体（PPAR）介导的疾病中具有用途，如X综合征、2型糖尿病、高血糖、高脂血症、肥胖、凝血障碍、高血压、动脉硬化以及与X综合征和心血管疾病相关的其他疾病。
• [EN] METHODS OF TREATING OR PREVENTING PSORIASIS, AND/OR ALZHEIMER'S DISEASE USING INDANE ACETIC ACID DERIVATIVES<br/>[FR] PROCÉDÉ DE TRAITEMENT PRÉVENTIF OU CURATIF DU PSORIASIS ET/OU DE LA MALADIE D'ALZHEIMER AU MOYEN DE DÉRIVÉS INDANE D'ACIDE ACÉTIQUE
  申请人：DARA BIOSCIENCES INC

  公开号：WO2010141696A1

  公开（公告）日：2010-12-09

  The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing psoriasis and/or Alzheimer's diseases.

  本发明提供了茚乙酸及其衍生物，以及用于治疗和/或预防牛皮癣和/或阿尔茨海默病的方法。
• METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES
  申请人：T3D Therapeutics, Inc.

  公开号：US20180153860A1

  公开（公告）日：2018-06-07

  The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders.

  本发明提供了茚乙酸及其衍生物，以及用于治疗和/或预防认知障碍的方法。