N-(3-methylbenzyl)-9H-pyrimido[5,4-c]tetrazolo[1,5-a][1,5]benzodiazepin-11-amine | 1313713-69-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(3-methylbenzyl)-9H-pyrimido[5,4-c]tetrazolo[1,5-a][1,5]benzodiazepin-11-amine
• 英文别名: N-[(3-methylphenyl)methyl]-2,3,4,5,9,11,13-heptazatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),3,5,7,9,11,14,16-octaen-10-amine
• CAS: 1313713-69-7
• 化学式: C₁₉H₁₆N₈
• 分子量: 356.39
• InChiKey: LLXYFQYHQHLABI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  93.4
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Substituted Benzo-Pyrimido-Tetrazolo-Diazepine Compounds
  申请人：Yang Rui-Yang

  公开号：US20110166127A1

  公开（公告）日：2011-07-07

  The present invention relates to substituted benzo-pyrimido-tetrazolo-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-pyrimido-tetrazolo-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及替代苯并嘧啶-四氮唑-二氮杂环庚烷化合物及其合成方法。本发明还涉及含有替代苯并嘧啶-四氮唑-二氮杂环庚烷化合物的药物组合物，以及通过向需要的受试者投予这些化合物和药物组合物来治疗细胞增殖性疾病，如癌症的方法。
• US8470812B2
  申请人：——

  公开号：US8470812B2

  公开（公告）日：2013-06-25
• [EN] SUBSTITUTED BENZO-PYRIMIDO-TETRAZOLO-DIAZEPINE COMPOUNDS<br/>[FR] COMPOSÉS DE BENZO-PYRIMIDO-TÉTRAZOLO-DIAZÉPINE SUBSTITUÉE
  申请人：ARQULE INC

  公开号：WO2011082269A2

  公开（公告）日：2011-07-07

  The present invention relates to substituted benzo-pyrimido-tetrazolo- diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-pyrimido-tetrazolo- diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.