| 375388-35-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• CAS: 375388-35-5
• 化学式: C₆₆H₁₃NO₂
• 分子量: 851.835
• InChiKey: DTGPQDMUTAGALL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.62
• 重原子数：
  69.0
• 可旋转键数：
  5.0
• 环数：
  33.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  32.7
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  BOC-甘氨酸 、 在 N,N'-二环己基碳二亚胺 、 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 24.5h， 以78%的产率得到
  参考文献：
  名称：

  Synthesis of a proline-rich [60]fullerene peptide with potential biological activity

  摘要：

  A proline-rich [60]fullerene peptide was synthesized by use of (i) a 1,3-dipolar cycloaddition of an N-substituted glycine derivative to [60]fullerene, (ii) esterification of the isolated alcohol with the C-terminal amino acid of the desired peptide sequence, and finally (iii) coupling of the remaining hexapeptide to give the final product 8 as a TFA salt, with oxidized methionine. Product 8 was found to be biologically active against sera from MCTD and SLE patients (ELISA experiment). (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.01.064
• 作为产物：
  描述：

  聚合甲醛 、 足球烯 、 N-2-(2-aminoethoxy-ethanol)-glycine 以 乙醇 、 甲苯 为溶剂， 反应 18.0h， 以44%的产率得到
  参考文献：
  名称：

  Synthesis of a proline-rich [60]fullerene peptide with potential biological activity

  摘要：

  A proline-rich [60]fullerene peptide was synthesized by use of (i) a 1,3-dipolar cycloaddition of an N-substituted glycine derivative to [60]fullerene, (ii) esterification of the isolated alcohol with the C-terminal amino acid of the desired peptide sequence, and finally (iii) coupling of the remaining hexapeptide to give the final product 8 as a TFA salt, with oxidized methionine. Product 8 was found to be biologically active against sera from MCTD and SLE patients (ELISA experiment). (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.01.064