4'-Hydroxybiphenyl-4-carboxylic acid | 203718-39-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-Hydroxybiphenyl-4-carboxylic acid
• 英文别名: 3'-nitro-4'-hydroxybiphenyl-4-carboxylic acid；4-(4-Carboxyphenyl)-2-nitrophenol；4-(4-hydroxy-3-nitrophenyl)benzoic acid
• CAS: 203718-39-2
• 化学式: C₁₃H₉NO₅
• 分子量: 259.218
• InChiKey: YFLVBXPEJDUFQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4'-Hydroxybiphenyl-4-carboxylic acid 在 4-二甲氨基吡啶 、 氢氧化钾 、 N,N'-二环己基碳二亚胺 、 potassium iodide 作用下， 以 二氯甲烷 为溶剂， 反应 30.0h， 生成
  参考文献：
  名称：

  Effects of nitro substituents on the properties of a ferroelectric liquid crystalline side chain polysiloxane

  摘要：

  本文描述了具有侧链硝基取代基和介晶核心的手性液晶侧链聚硅氧烷的合成。研究并比较了取代基及其位置对相行为和电光性质的影响。侧链前体及液晶聚合物的相行为受到侧向硝基的强烈影响。讨论了在层状A相和C*相中各取代基位置的性质。一种侧链前体表现出约700 nC cm–2的非常大自发极化。

  DOI：

  10.1039/a704918h
• 作为产物：
  描述：

  4'-methoxy-3'-nitro-biphenyl-4-carboxylic acid 在 氢溴酸 、 溶剂黄146 作用下， 生成 4'-Hydroxybiphenyl-4-carboxylic acid
  参考文献：
  名称：

  Effects of nitro substituents on the properties of a ferroelectric liquid crystalline side chain polysiloxane

  摘要：

  本文描述了具有侧链硝基取代基和介晶核心的手性液晶侧链聚硅氧烷的合成。研究并比较了取代基及其位置对相行为和电光性质的影响。侧链前体及液晶聚合物的相行为受到侧向硝基的强烈影响。讨论了在层状A相和C*相中各取代基位置的性质。一种侧链前体表现出约700 nC cm–2的非常大自发极化。

  DOI：

  10.1039/a704918h

文献信息

• New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20040242572A1

  公开（公告）日：2004-12-02

  The present invention relates to carboxamide compounds of general formula I 1 wherein the groups and residues A, B, W, X, Y, Z, R 1 , R 2 , R 3 and k have the meanings given in claim 1. Moreover the invention relates to process for preparing the above mentioned carboxamides as well as pharmaceutical compositions containing at least one carboxamide according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.

  本发明涉及具有通式I的羧酰胺化合物 1 其中，A、B、W、X、Y、Z、R 1 、R 2 、R 3 和k的含义如权利要求1中所述。此外，本发明还涉及制备上述羧酰胺的方法以及含有至少一种根据本发明的羧酰胺的药物组合物。由于它们对MCH受体的拮抗活性，根据本发明的药物组合物适合用于治疗代谢紊乱和/或饮食紊乱，特别是肥胖症、厌食症、暴食症、糖尿病。
• Thrombopoietin mimetics
  申请人：——

  公开号：US20040019190A1

  公开（公告）日：2004-01-29

  Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy- 1 -azobenzene derivative.

  发明了非肽类TPO类似物。还发明了用于制备目前发明的化合物的新工艺和中间体。还发明了一种治疗血小板减少症的方法，包括给予需要的哺乳动物，包括人类，有效量的选择性羟基-1-偶氮苯衍生物。
• THROMBOPOIETIN MIMETICS
  申请人：Duffy Kevin J.

  公开号：US20130078213A1

  公开（公告）日：2013-03-28

  Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

  本发明涉及非肽类TPO类似物的发明。本发明还涉及用于制备目前发明的化合物的新型过程和中间体。本发明还涉及一种治疗血小板减少症的方法，包括在需要的哺乳动物（包括人类）中给予所选的羟基-1-偶氮苯衍生物的有效量。
• Phase Transitions of 4‘-<i>n</i>-Hexacosyloxy-3‘-nitrobiphenyl-4-carboxylic Acid (ANBC-26):  Two Types of Thermotropic Cubic Phases
  作者：Shoichi Kutsumizu、Tatsuya Ichikawa、Minoru Yamada、Shuichi Nojima、Shinichi Yano

  DOI：10.1021/jp0018652

  日期：2000.11.1

  The phase transitions of 4'-n-hexacosyloxy-3'-nitrobiphenyl-4-carboxylic acid (ANBC-26, where "26" indicates the number of carbon atoms in the alkoxy group) were investigated by differential scanning calorimetric (DSC), polarizing optical microscopic, and X-ray diffraction (XRD) measurements. ANBC-26 is a new liquid crystalline material which exhibits successively two types of three-dimensionally ordered cubic mesophases on heating; the low-temperature cubic (CubI) phase has a space group of Im3m, and the high-temperature one (CubII phase) is of Ia3d type, identical with the cubic phase of shorter alkoxy chain homologues such as ANBC-16, and a cubic-cubic phase transition occurs at 435 K on DSC, Reversibility of the transitions between them was studied and the structures of those mesophases are discussed. The transformation from a one-dimensionally ordered smectic C (SmC) to the CubI phase and to the CubII phase can be interpreted qualitatively in terms of the increased curvature of the interface. The structured liquid Il phase, an intermediate phase between the CubII and a true isotropic liquid I-2 phases, has been also studied, indicating that this phase could be characterized by Ornstein-Zernike type short-range fluctuation, which means the presence of molecular clusters consisting of several ANBC-26 dimers in the temperature region.
• EP1294378A4
  申请人：——

  公开号：EP1294378A4

  公开（公告）日：2004-01-28