3-amino-1-morpholin-4-yl-propan-1-one; compound with phenylacetic acid | 442851-35-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-amino-1-morpholin-4-yl-propan-1-one; compound with phenylacetic acid
• 英文别名: 3-Amino-1-morpholin-4-ylpropan-1-one;2-phenylacetic acid
• CAS: 442851-35-6
• 化学式: C₇H₁₄N₂O₂*C₈H₈O₂
• 分子量: 294.351
• InChiKey: DJNPTDIYFPCYPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.51
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  97.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-amino-1-(morpholin-4-yl)propan-1-one 、 盐酸 、 sodium methylate 、 苯乙酸 在 氮 作用下， 以 甲醇 为溶剂， 反应 0.33h， 以to provide 3-amino-1-morpholin-4-yl-propan-1-one; compound with phenylacetic acid (191 g)的产率得到3-amino-1-morpholin-4-yl-propan-1-one; compound with phenylacetic acid
  参考文献：
  名称：

  Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrole-3-carboxylic acid and phenylamide

  摘要：

  本文描述了一种改进的工艺，通过一种新的合成方法，将甲基氰乙酸酯转化为所需产物，即5-(4-氟苯基)-1-[2-((2R,4R)-4-羟基-6-氧代-四氢吡喃-2-基)-乙基]-2-异丙基-4-苯基-1H-吡咯烷-3-羧酸苯酰胺，该工艺仅需进行八次或更少的操作，同时还使用了其他有价值的中间体。

  公开号：

  US20070032662A1

文献信息

• Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1eta-pyrrole-3-carboxylic acid phenylamide
  申请人：Butler Eugene Donald

  公开号：US20050239869A1

  公开（公告）日：2005-10-27

  An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.

  一种改进的制备5-(4-氟苯基)-1-[2-((2R,4R)-4-羟基-6-氧代-四氢吡喃-2-基)-乙基]-2-异丙基-4-苯基-1H-吡咯烷-3-羧酸苯胺的方法被描述，其中甲基氰乙酸酯经过八次或更少的操作转化为所需的产物，以及在该过程中使用的其他有价值的中间体。
• Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo- tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
  申请人：——

  公开号：US20030195353A1

  公开（公告）日：2003-10-16

  An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.

  本发明描述了一种改进的工艺，用于通过新的合成方法制备5-(4-氟苯基)-1-[2-((2R,4R)-4-羟基-6-氧代四氢吡喃-2-基)-乙基]-2-异丙基-4-苯基-1H-吡咯烷-3-羧酸苯酰胺，其中甲基氰乙酸酯通过八个或更少的操作转化为所需的产物，以及用于该过程的其他有价值的中间体。
• NOVEL PROCESS FOR THE SYNTHESIS OF 5-(4-FLUOROPHENYL)-1-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-2-ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID PHENYLAMIDE
  申请人：——

  公开号：US20020133026A1

  公开（公告）日：2002-09-19

  An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.

  本文描述了一种改进的制备5-(4-氟苯基)-1-［2-［（2R，4R）-4-羟基-6-氧代-四氢-吡喃-2-基］-乙基］-2-异丙基-4-苯基-1H-吡咯烷-3-羧酸苯酰胺的新型合成方法，其中甲基氰乙酸酯经过八次或更少的操作转化为所需的产物，以及在该过程中使用的其他有价值的中间体。
• Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
  申请人：Warner-Lambert Company

  公开号：US06476235B2

  公开（公告）日：2002-11-05

  An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.

  本文描述了一种改进的工艺，通过一种新的合成方法，将甲基氰乙酸酯转化为所需产物5-(4-氟苯基)-1-[2-((2R,4R)-4-羟基-6-氧代四氢吡喃-2-基)-乙基]-2-异丙基-4-苯基-1H-吡咯烷-3-羧酸苯酰胺，仅需进行八次或更少的操作即可制得所需产品，同时还制备了其他有用的中间体，用于该工艺。
• Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
  申请人：Warner-Lambert Company, LLC

  公开号：US07183408B2

  公开（公告）日：2007-02-27

  An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.

  描述了一种改进的方法，通过一种新的合成方法，将甲基氰乙酸酯在八个步骤或更少的步骤中转化为所需的产物5-(4-氟苯基)-1-[2-((2R,4R)-4-羟基-6-氧代四氢吡喃-2-基)-乙基]-2-异丙基-4-苯基-1H-吡咯烷-3-羧酸苯酰胺，以及在该过程中使用的其他有价值的中间体。