4-[3-({4-[4-(2-Hydroxyethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]phenyl}thio) phenyl]tetrahydro-2H-pyran-4-carboxamide | 950205-51-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[3-({4-[4-(2-Hydroxyethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]phenyl}thio) phenyl]tetrahydro-2H-pyran-4-carboxamide
• 英文别名: 4-[3-[4-[4-(2-Hydroxyethyl)-5-oxo-1,2,4-triazol-1-yl]phenyl]sulfanylphenyl]oxane-4-carboxamide
• CAS: 950205-51-3
• 化学式: C₂₂H₂₄N₄O₄S
• 分子量: 440.523
• InChiKey: JZHMLHQWZOIJLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  134
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• 5-LIPOXYGENASE INHIBITORS
  申请人：Verma Kumar Ashwani

  公开号：US20080021080A1

  公开（公告）日：2008-01-24

  The present invention relates to 5-lipoxygenase inhibitors. Compounds disclosed herein can be useful in the treatment of bronchial asthma, chronic obstructive pulmonary disorder, arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, urticaria, atopic dermatitis, allergic rhinitis, other inflammatory and autoimmune diseases. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as 5-lipoxygenase inhibitors are also provided.

  本发明涉及5-脂氧酶抑制剂。本文所披露的化合物可用于治疗支气管哮喘、慢性阻塞性肺疾病、关节炎、1型糖尿病、多发性硬化症、移植排斥、银屑病、炎症性肠病、溃疡性结肠炎、痤疮、动脉粥样硬化、癌症、瘙痒、荨麻疹、特应性皮炎、过敏性鼻炎和其他炎症性和自身免疫性疾病的治疗。本文还提供了所披露化合物的制备方法、含有所披露化合物的制药组合物以及它们作为5-脂氧酶抑制剂的用途。
• Tetrahydropyrane derivatives as 5-lipoxygenase inhibitors
  申请人：Ranbaxy Laboratories Limited

  公开号：EP1834953A1

  公开（公告）日：2007-09-19

  The present invention relates to 5-lipoxygenase inhibitors of formula I. Compounds disclosed herein can be useful in the treatment of bronchial asthma, chronic obstructive pulmonary disorder, arthritis, type 1 diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, urticaria, atopic dermatitis, allergic rhinitis, other inflammatory and autoimmune diseases. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as 5-lipoxygenase inhibitors are also provided.

  本发明涉及式I的5-脂氧合酶抑制剂。本文所披露的化合物可用于治疗支气管哮喘、慢性阻塞性肺疾病、关节炎、1型糖尿病、多发性硬化症、移植排斥、牛皮癣、炎症性肠病、溃疡性结肠炎、痤疮、动脉粥样硬化、癌症、瘙痒、荨麻疹、特应性皮炎、过敏性鼻炎以及其他炎症和自身免疫性疾病的治疗。本文还提供了所披露的化合物的制备方法、含有所披露的化合物的制药组合物以及它们作为5-脂氧合酶抑制剂的用途。
• US7674811B2
  申请人：——

  公开号：US7674811B2

  公开（公告）日：2010-03-09