4-氯-2-甲氧基-6-[(4-甲氧基苯基)甲基]嘧啶 | 143467-63-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 4-氯-2-甲氧基-6-[(4-甲氧基苯基)甲基]嘧啶
• 英文名称: 4-chloro-2-methoxy-6-(4-methoxybenzyl)pyrimidine
• 英文别名: Pyrimidine, 4-chloro-2-methoxy-6-((4-methoxyphenyl)methyl)-；4-chloro-2-methoxy-6-[(4-methoxyphenyl)methyl]pyrimidine
• CAS: 143467-63-4
• 化学式: C₁₃H₁₃ClN₂O₂
• 分子量: 264.711
• InChiKey: ZIKQZQBVRZHPGS-UHFFFAOYSA-N

物化性质

• 沸点：
  404.6±55.0 °C(Predicted)
• 密度：
  1.229±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-氯-2-甲氧基-6-[(4-甲氧基苯基)甲基]嘧啶 在 一水合肼 作用下， 反应 2.0h， 生成
  参考文献：
  名称：

  Synthesis, antimicrobial and antiviral activities of isotrimethoprim and some related derivatives

  摘要：

  The synthesis and the antimicrobial activities of 2,4-diamino-6-(3,4.5-trimethoxvbenzyl)pyrimidine (isotrimethoprim) and some related derivatives are reported. The new derivatives have been found scarcely active against bacteria and fungi, with the only exception of 4-chloro-2-methoxypyrimidinyl-3,4,5-trimethoxyphenyldichloromethane, which showed good antibacterial activity against Staphylococcus aureus. Cytotoxicity and antiviral assays, HIV included, have also been determined in comparison with TMP and AZT. Little but selective activity was shown by some derivatives against HIV retrovirus.

  DOI：

  10.1016/0223-5234(92)90009-p
• 作为产物：
  描述：

  6-(4-methoxybenzyl)-2-methoxy-4(3H)-pyrimidinone 在 三氯氧磷 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以68%的产率得到4-氯-2-甲氧基-6-[(4-甲氧基苯基)甲基]嘧啶
  参考文献：
  名称：

  Synthesis, antimicrobial and antiviral activities of isotrimethoprim and some related derivatives

  摘要：

  The synthesis and the antimicrobial activities of 2,4-diamino-6-(3,4.5-trimethoxvbenzyl)pyrimidine (isotrimethoprim) and some related derivatives are reported. The new derivatives have been found scarcely active against bacteria and fungi, with the only exception of 4-chloro-2-methoxypyrimidinyl-3,4,5-trimethoxyphenyldichloromethane, which showed good antibacterial activity against Staphylococcus aureus. Cytotoxicity and antiviral assays, HIV included, have also been determined in comparison with TMP and AZT. Little but selective activity was shown by some derivatives against HIV retrovirus.

  DOI：

  10.1016/0223-5234(92)90009-p

文献信息

• Synthesis, antimicrobial and antiviral activities of isotrimethoprim and some related derivatives
  作者：M Botta、M Artico、S Massa、A Gambacorta、ME Marongiu、A Pani、P La Colla

  DOI：10.1016/0223-5234(92)90009-p

  日期：1992.4

  The synthesis and the antimicrobial activities of 2,4-diamino-6-(3,4.5-trimethoxvbenzyl)pyrimidine (isotrimethoprim) and some related derivatives are reported. The new derivatives have been found scarcely active against bacteria and fungi, with the only exception of 4-chloro-2-methoxypyrimidinyl-3,4,5-trimethoxyphenyldichloromethane, which showed good antibacterial activity against Staphylococcus aureus. Cytotoxicity and antiviral assays, HIV included, have also been determined in comparison with TMP and AZT. Little but selective activity was shown by some derivatives against HIV retrovirus.