methyl 3-(benzyloxy)-5-(5-(4-methoxybenzyloxy)-2-nitrophenylamino)thiophene-2-carboxylate | 1276687-29-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 3-(benzyloxy)-5-(5-(4-methoxybenzyloxy)-2-nitrophenylamino)thiophene-2-carboxylate
• 英文别名: Methyl 5-[5-[(4-methoxyphenyl)methoxy]-2-nitroanilino]-3-phenylmethoxythiophene-2-carboxylate
• CAS: 1276687-29-6
• 化学式: C₂₇H₂₄N₂O₇S
• 分子量: 520.563
• InChiKey: DYEONTHPEVHUQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  37
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  140
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  methyl 3-(benzyloxy)-5-(5-(4-methoxybenzyloxy)-2-nitrophenylamino)thiophene-2-carboxylate 在 偶氮二甲酸二叔丁酯 、 palladium 10% on activated carbon 、 氢气 、 4-甲基苯磺酸吡啶 、 三苯基膦 、 三氟乙酸 作用下， 以 乙醇 、 二氯甲烷 、 水 、 乙酸乙酯 为溶剂， 生成 tert-butyl 4-(1-(5-(methoxycarbonyl)-4-(2-(trifluoromethyl)benzyloxy)thiophen-2-yl)-1H-benzo[d]imidazol-6-yloxy)piperidine-1-carboxylate
  参考文献：
  名称：

  Benzimidazole Inhibitors Induce a DFG-Out Conformation of Never in Mitosis Gene A-Related Kinase 2 (Nek2) without Binding to the Back Pocket and Reveal a Nonlinear Structure−Activity Relationship

  摘要：

  We describe herein the structure-activity relationship (SAR) and cocrystal structures of a series of Nek2 inhibitors derived from the published polo-like kinase 1 (Plk1) inhibitor (R)-1. Our studies reveal a nonlinear SAR for Nek2 and our cocrystal structures show that compounds in this series bind to a DFG-out conformation of Nek2 without extending into the enlarged back pocket commonly found in this conformation. These observations were further investigated, and structure-based design led to Nek2 inhibitors derived from (R)-1 with more than a hundred-fold selectivity against Plk1.

  DOI：

  10.1021/jm1011726
• 作为产物：
  描述：

  methyl 3-(benzyloxy)-5-nitrothiophene-2-carboxylate 在 tris-(dibenzylideneacetone)dipalladium(0) 、 铁粉 、 caesium carbonate 、 溶剂黄146 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 生成 methyl 3-(benzyloxy)-5-(5-(4-methoxybenzyloxy)-2-nitrophenylamino)thiophene-2-carboxylate
  参考文献：
  名称：

  Benzimidazole Inhibitors Induce a DFG-Out Conformation of Never in Mitosis Gene A-Related Kinase 2 (Nek2) without Binding to the Back Pocket and Reveal a Nonlinear Structure−Activity Relationship

  摘要：

  We describe herein the structure-activity relationship (SAR) and cocrystal structures of a series of Nek2 inhibitors derived from the published polo-like kinase 1 (Plk1) inhibitor (R)-1. Our studies reveal a nonlinear SAR for Nek2 and our cocrystal structures show that compounds in this series bind to a DFG-out conformation of Nek2 without extending into the enlarged back pocket commonly found in this conformation. These observations were further investigated, and structure-based design led to Nek2 inhibitors derived from (R)-1 with more than a hundred-fold selectivity against Plk1.

  DOI：

  10.1021/jm1011726

文献信息

• Benzimidazole Inhibitors Induce a DFG-Out Conformation of Never in Mitosis Gene A-Related Kinase 2 (Nek2) without Binding to the Back Pocket and Reveal a Nonlinear Structure−Activity Relationship
  作者：Savade Solanki、Paolo Innocenti、Corine Mas-Droux、Kathy Boxall、Caterina Barillari、Rob L. M. van Montfort、G. Wynne Aherne、Richard Bayliss、Swen Hoelder

  DOI：10.1021/jm1011726

  日期：2011.3.24

  We describe herein the structure-activity relationship (SAR) and cocrystal structures of a series of Nek2 inhibitors derived from the published polo-like kinase 1 (Plk1) inhibitor (R)-1. Our studies reveal a nonlinear SAR for Nek2 and our cocrystal structures show that compounds in this series bind to a DFG-out conformation of Nek2 without extending into the enlarged back pocket commonly found in this conformation. These observations were further investigated, and structure-based design led to Nek2 inhibitors derived from (R)-1 with more than a hundred-fold selectivity against Plk1.