ζ-aminohexylglycine | 143192-21-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ζ-aminohexylglycine
• 英文别名: N-(6-aminohexyl) glycine；N-(6-aminohexyl)glycine；2-(6-aminohexylamino)acetic acid
• CAS: 143192-21-6
• 化学式: C₈H₁₈N₂O₂
• 分子量: 174.243
• InChiKey: NOCTZBYMEXZKLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ζ-aminohexylglycine 在 盐酸 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 25.0h， 生成 Methyl 2-[6-(phenylmethoxycarbonylamino)hexylamino]acetate
  参考文献：
  名称：

  Building units for N-backbone cyclic peptides. 1. Synthesis of protected N-(.omega.-aminoalkylene)amino acids and their incorporation into dipeptide units

  摘要：

  A variety of new amino acids which contain an omega-aminoalkylene group on the N(alpha)-amino nitrogen were synthesized by alkylation of alkylenediamines with alpha-halogeno acids. The reaction proceeds with inversion of configuration; thus, optically pure products were obtained when optically active a-halogeno acids were used. The N-(omega-aminoalkylene)amino acids were protected by orthogonal protecting groups to allow their incorporation into dipeptides by the "solution" techniques and into peptides by the solid-phase peptide synthesis (SPPS) methodology. A series of dipeptide analogs of Phe-Gly, Leu-Gly, Trp-Gly, Phe-Leu, and Phe-Ala in which the nitrogen of the peptide bond is alkylated by omega-aminoalkylene chains with various lengths were prepared. These new protected N-(omega-aminoalkylene)amino acids and their derived dipeptide units may be used as building blocks for conformationally constrained N-backbone cyclic peptides.

  DOI：

  10.1021/jo00047a022
• 作为产物：
  描述：

  1,6-己二胺 、 alkaline earth salt of/the/ methylsulfuric acid 以 二氯甲烷 为溶剂， 反应 48.0h， 生成 ζ-aminohexylglycine
  参考文献：
  名称：

  Building units for N-backbone cyclic peptides. 1. Synthesis of protected N-(.omega.-aminoalkylene)amino acids and their incorporation into dipeptide units

  摘要：

  A variety of new amino acids which contain an omega-aminoalkylene group on the N(alpha)-amino nitrogen were synthesized by alkylation of alkylenediamines with alpha-halogeno acids. The reaction proceeds with inversion of configuration; thus, optically pure products were obtained when optically active a-halogeno acids were used. The N-(omega-aminoalkylene)amino acids were protected by orthogonal protecting groups to allow their incorporation into dipeptides by the "solution" techniques and into peptides by the solid-phase peptide synthesis (SPPS) methodology. A series of dipeptide analogs of Phe-Gly, Leu-Gly, Trp-Gly, Phe-Leu, and Phe-Ala in which the nitrogen of the peptide bond is alkylated by omega-aminoalkylene chains with various lengths were prepared. These new protected N-(omega-aminoalkylene)amino acids and their derived dipeptide units may be used as building blocks for conformationally constrained N-backbone cyclic peptides.

  DOI：

  10.1021/jo00047a022

文献信息

• NOVEL DIAMINE, POLYAMIC ACID, AND POLYIMIDE
  申请人：NISSAN CHEMICAL INDUSTRIES. LTD.

  公开号：US20160264520A1

  公开（公告）日：2016-09-15

  To provide a novel diamine, and a polyimide precursor and a polyimide using it. A diamine represented by the formula (1): wherein each of X 1 and X 5 which are independent of each other, is a single bond or the like; each of X 2 and X 4 which are independent of each other, is —CH 2 — or the like; X 3 is a C 1-6 alkylene or the like; each of Y 1 and Y 2 which are independent of each other, is a single bond or the like; R is a C 1-20 linear, branched or cyclic hydrocarbon group; and a is 0 or 1).

  提供一种新颖的二胺，以及使用它的聚酰亚胺前体和聚酰亚胺。一种由式（1）表示的二胺：其中X1和X5中的每一个独立的，是单键或类似物；X2和X4中的每一个独立的，是—CH2—或类似物；X3是C1-6烷基或类似物；Y1和Y2中的每一个独立的，是单键或类似物；R是C1-20线性、支链或环烃基；a为0或1。
• [EN] CYCLIC PEPTOID OLIGOMERS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME<br/>[FR] OLIGOMÈRES PEPTOÏDES CYCLIQUES, COMPOSITIONS PHARMACEUTIQUES LES COMPRENANT ET PROCÉDÉS D'UTILISATION ASSOCIÉS
  申请人：UNIV NEW YORK

  公开号：WO2014159937A1

  公开（公告）日：2014-10-02

  Novel peptoid oligomers are disclosed that have a formula represented by the following formula I: wherein R1 and n are as described herein. The peptoids demonstrate antimicrobial and antimalarial activity and may be prepared as pharmaceutical compositions and used for the prevention or treatment of a variety of conditions in mammals including humans where microbial or malarial infection is involved. The present cyclic peptoids are particularly valuable as their effect is rapid, broad in spectrum and mostly indifferent to resistance provoked by standard antibiotics.

  本发明披露了具有以下I式表示的公式的新型肽类寡聚物：其中R1和n如本文所述。这些肽类表现出抗微生物和抗疟疾活性，可制备为药物组合物，并用于哺乳动物中包括人类的各种条件的预防或治疗，其中涉及微生物或疟疾感染。本发明的环肽类尤其有价值，因为它们的效果快速，广谱，而且对于标准抗生素引起的耐药性大多是无效的。
• LHRH-II PEPTIDE ANALOGS
  申请人：Linder Karen E.

  公开号：US20120045393A1

  公开（公告）日：2012-02-23

  The invention is directed to analogs of LHRH-II and, more generally, to analogs of the LHRH family in which modifications have been made that confer enhanced binding affinity for LHRH receptors and/or improved metabolic stability. The invention is further directed to methods of targeted therapy and targeted imaging in patients with sex-hormone-related cancers or other LHRH-mediated diseases.

  该发明涉及LHRH-II的类似物，更一般地，涉及LHRH家族的类似物，其中进行了改性以赋予LHRH受体更强的结合亲和力和/或改善代谢稳定性。该发明进一步涉及在患有性激素相关癌症或其他LHRH介导疾病的患者中进行有针对性的治疗和有针对性的成像的方法。
• Diamine, polyamic acid, and polyimide
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US10023530B2

  公开（公告）日：2018-07-17

  To provide a novel diamine, and a polyimide precursor and a polyimide using it. A diamine represented by the formula (1): wherein each of X1 and X5 which are independent of each other, is a single bond or the like; each of X2 and X4 which are independent of each other, is —CH2— or the like; X3 is a C1-6 alkylene or the like; each of Y1 and Y2 which are independent of each other, is a single bond or the like; R is a C1-20 linear, branched or cyclic hydrocarbon group; and a is 0 or 1).

  提供一种新型二胺、一种聚酰亚胺前体和一种使用该二胺的聚酰亚胺。由式（1）表示的二胺： 其中相互独立的 X1 和 X5 各为单键或类似物；相互独立的 X2 和 X4 各为-CH2-或类似物；X3 为 C1-6 亚烷基或类似物；相互独立的 Y1 和 Y2 各为单键或类似物；R 为 C1-20 直链、支链或环状烃基；a 为 0 或 1）。
• PEPTOID OLIGOMERS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME
  申请人：New York University

  公开号：EP2401264A2

  公开（公告）日：2012-01-04