4-(1H-benzimidazol-2-yl)-N-[(4-bromophenyl)methylideneamino]benzamide | 1237050-20-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 4-(1H-benzimidazol-2-yl)-N-[(4-bromophenyl)methylideneamino]benzamide
• CAS: 1237050-20-2
• 化学式: C₂₁H₁₅BrN₄O
• 分子量: 419.28
• InChiKey: WVPVGHRYTKYZBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.76
• 重原子数：
  27.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.14
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  4-(1H-benzimidazole-2-yl)-benzohydrazide 、 对溴苯甲醛 在 溶剂黄146 作用下， 以 正丁醇 为溶剂， 反应 3.0h， 以80%的产率得到4-(1H-benzimidazol-2-yl)-N-[(4-bromophenyl)methylideneamino]benzamide
  参考文献：
  名称：

  Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazone moiety

  摘要：

  In this study 12 novel benzimidazole compounds bearing hydrazone moiety were synthesized in order to investigate their possible antibacterial and antifungal activity. Structures of the synthesized compounds were elucidated by spectral data. Six different gram-negative and four different gram-positive bacterial strains were used in antibacterial activity tests. Antifungal activity tests were also performed against three different fungal strains. Most of the test compounds found to be significantly effective against Proteus vulgaris, Staphylococcus typhimurium, Klebsiella pneumoniae and Pseudomonas aeruginosa gram-negative bacterial strains. A structure activity relationship (SAR) study including some electronic parameters was carried out and a connection between antibacterial activity and electronic properties of the target compounds was determined. Toxicity of the most effective compounds was established by performing Brine Shrimp lethality assay. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.04.012