{3-Decyloxy-5-[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-phenyl}-methanol | 870094-61-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: {3-Decyloxy-5-[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-phenyl}-methanol
• CAS: 870094-61-4
• 化学式: C₂₈H₅₀O₈
• 分子量: 514.7
• InChiKey: VUSUFSINGIQECF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.79
• 重原子数：
  36.0
• 可旋转键数：
  27.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  84.84
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  {3-Decyloxy-5-[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-phenyl}-methanol 在 Jones reagent 、 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 32.0h， 生成
  参考文献：
  名称：

  低聚物引发响应型液晶

  摘要：

  我们报告了两亲低聚物的水溶液对热致液晶（LCs）的微米厚膜的有序化的影响的调查，从而解决了以前对单体和聚合物两亲与LCs相互作用的研究所产生的知识空白。具体来说，我们合成了单体，二聚体和三聚体形式的两亲性低聚物（具有癸基疏水性和五乙二醇亲水性结构域），并将该低聚物的水溶液与4'-戊基-4-联苯甲腈（5CB）的向列膜温育。所有两亲性低聚物都导致顺序地进行表面驱动的取向（平面至垂直），然后发生本体相转变（向列至各向同性），其动力学很大程度上取决于低聚度。定向转变的动力学从单体加速到三聚体，这与吸附自由能增加的影响一致。然而，定向过渡的机制涉及锚固能量的减少，而LC的易轴却没有变化。相反，由低聚物吸收到LC中引起的相变速率从单体到三聚体降低，这表明对构型自由度的限制会影响低聚物的吸收自由能。有趣的是，观察到低聚物诱导的5CB向列相向各向同性相的转变在水–5CB界面成核，这与上述由低聚物引起的锚定

  DOI：

  10.1021/acs.langmuir.8b01944
• 作为产物：
  描述：

  2-[2-[2-[2-(2-甲氧基乙氧基)乙氧基]乙氧基]乙氧基]乙醇,4-甲基苯磺酸 、 3-decyloxy-5-hydroxybenzyl alcohol 在 18-冠醚-6 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 以96%的产率得到{3-Decyloxy-5-[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-phenyl}-methanol
  参考文献：
  名称：

  Invertible amphiphilic polymers

  摘要：

  具有两性单体化合物及相应的同聚物和共聚物能够在流体介质中进行组装和可逆配置。

  公开号：

  US20070293669A1

文献信息

• Temperature-Sensitive Dendritic Micelles
  作者：Sivakumar V. Aathimanikandan、Elamprakash N. Savariar、S. Thayumanavan

  DOI：10.1021/ja054542y

  日期：2005.10.1

  Syntheses up to three generations have been achieved of biaryl-based amphiphilic dendrons with a charge-neutral pentaethylene glycol as the hydrophilic part and a decyl chain as the hydrophobic part. Studies on the temperature-dependent characteristics revealed that these dendrons exhibit a generation-dependent lower critical solution temperature (LCST). This behavior is attributed to the combination of the amphipathic nature of the hydrophilic pentaethylene glycol side chain and dendritic effect. Interestingly, this biaryl-based scaffold also maintains the ability to form a micelle-like assembly in polar solvents and an inverted micelle-like assembly in apolar solvents. Polarity of the dendritic interior was investigated using dye-based microenvironment studies. The aggregation behavior of these micelles was analyzed by fluorescence spectroscopy and dynamic light scattering. Critical micelle concentrations (CMC) of these assemblies were investigated using fluorescence excitation spectra of the sequestered guest molecule, pyrene.
• Influence of Backbone Conformational Rigidity in Temperature-Sensitive Amphiphilic Supramolecular Assemblies
  作者：Krishna R. Raghupathi、Uma Sridhar、Kevin Byrne、Kishore Raghupathi、S. Thayumanavan

  DOI：10.1021/jacs.5b02108

  日期：2015.4.29

  Molecular design, features that, endow amphiphilic supramolecular assemblies with a unique temperature-sensitive transition have been investigated. We find that conformational rigidity in the backbone IS an important feature for eliciting this feature. We also find that intramolecular hydrogen-bonding can in-duce such rigidity in amphiphile backbone. Guest encapsulation stability of these assemblies was found to be significantly altered Within, a narrow temperature window, which correlates with the temperature-sensitive size transition of the molecular assembly. Molecular design principles demonstrated here,could have broad implications in developing future temperature-responsive systems.