Boc-dmaPhe-OH | 105115-92-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-dmaPhe-OH
• 英文别名: (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(dimethylamino)phenyl)propanoic acid；(2S)-3-[4-(dimethylamino)phenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
• CAS: 105115-92-2
• 化学式: C₁₆H₂₄N₂O₄
• 分子量: 308.378
• InChiKey: HJYHALYYDSUJMF-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Boc-dmaPhe-OH 在 盐酸 、 N-羟基丁二酰亚胺 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 Bu^tCO-D-Pro-L-Phe(p-NMe2)-NHMe
  参考文献：
  名称：

  Tamiaki, Hitoshi; Maruyama, Kazuhiro, Journal of the Chemical Society. Perkin transactions I, 1992, # 18, p. 2431 - 2436

  摘要：

  DOI：
• 作为产物：
  描述：

  聚合甲醛 、 BOC-L-4-硝基苯丙氨酸 在 palladium on activated charcoal 氢气 、 sodium acetate 作用下， 以 乙醇 为溶剂， 反应 36.0h， 生成 Boc-dmaPhe-OH
  参考文献：
  名称：

  单个 α-螺旋多肽链上的光诱导电子转移

  摘要：

  在 etudie le transfert d'electron intramoleculaire le long de l'helice α dupeptide 上的固定组发色团 sur des 多肽（contenant surtout des glutamates）。练习曲 est effectuee sur le肽模型 Boc-dmaPhe-Ala-pyr Ala-OMe

  DOI：

  10.1021/ja00199a044

文献信息

• Substituted hydantoins
  申请人：Goodnow, Alan Robert

  公开号：US20060063814A1

  公开（公告）日：2006-03-23

  The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.

  本发明涉及以下公式的化合物，这些化合物在治疗以MEK高活性为特征的疾病方面具有用途。因此，这些化合物在治疗癌症、认知和中枢神经系统疾病以及炎症/自身免疫疾病等疾病方面具有用途。
• Electric Field Effects on Electron Transfer Rates in Dichromophoric Peptides:  The Effect of Helix Unfolding
  作者：Marye Anne Fox、Elena Galoppini

  DOI：10.1021/ja963269k

  日期：1997.6.1

  The effect of helix unfolding on the rates of photoinduced electron transfer in model dichromophoric peptides was investigated. Two α-helical peptides, 1 and 2, having an alternating Ala-Aib backbone and differing only in the position of an appended electron donor (N,N-dimethylaniline) and an appended photoexcited electron acceptor (pyrene) relative to the electric field generated by the helix, had

  研究了螺旋解折叠对模型二发色肽中光致电子转移速率的影响。两种 α-螺旋肽，1 和 2，具有交替的 Ala-Aib 主链，仅在附加电子供体（N,N-二甲基苯胺）和附加光激发电子受体（芘）相对于产生的电场的位置不同通过螺旋，已经显示出光致电子转移速率的差异，这归因于螺旋偶极子效应。在被质子溶剂（EtOH、MeOH、H2O、CF3CH2OH）或胍变性后，1 和 2 中观察到的电子转移速率变得相同。通过圆二色性 (CD) 分析研究螺旋展开。第二对模型寡肽，3 和 4，与 1 和 2 类似，但制备了 L-脯氨酸 (Pro) 而不是 α-甲基丙氨酸 (Aib) 并入主链，以研究低介电常数溶剂中的未折叠肽。CD、NMR和稳态荧光光谱...
• Photoinduced electron transfer in a single .alpha.-helical polypeptide chain: evidence of a through-space mechanism
  作者：Yoshihito Inai、Masahiko Sisido、Yukio Imanishi

  DOI：10.1021/j100162a074

  日期：1991.5

  alpha-Helical polypeptides containing a single pair of L-p-(dimethylamino)phenylalanine and L-l-pyrenylalanine were synthesized. The distance and orientation of the (dimethylamino)phenyl (D) and pyreyl (P) group were varied by inserting different numbers (m) of L-alanine units between the two artificial aromatic amino acids. The edge-to-edge distances between D and P groups, predicted from conformational energy calculations, were 5.4 angstrom for m = 0, 9.4 angstrom for m = 1, and 5.5 angstrom for m = 2. This indicates that the D-P pair in the m = 2 polypeptide is separated by a larger number of bonds but located closer than the D-P pair in the m = 1 polypeptide. The D-P pair in the m = 0 polypeptide was arranged in a head-to-tail manner, but that in the m = 2 polypeptide had a face-to-face arrangement. The rates of photoinduced electron transfer (ET) from the D to P* group at -20-degrees-C in trimethyl phosphate solution were evaluated from the decay time of P* fluorescence to be 1.9 x 10(7) (m = 0), 6.6 x 10(5) (m = 1), and 2.1 x 10(7) s-1 (m = 2). The results show that the ET is occurring through space, and the possibility for a helical polypeptide chain as an electron mediator was excluded, at least for this relatively short distance ET. The ET rate was not very sensitive to the orientation of the donor and acceptor groups.
• Distance and orientation dependence of electron transfer and exciplex formation of naphthyl and p-dimethylanilino groups fixed on a helical polypeptide chain
  作者：Yoshihito. Inai、Masahiko. Sisido、Yukio. Imanishi

  DOI：10.1021/j100379a017

  日期：1990.8
• SUBSTITUTED HYDANTOINS FOR THE TREATMENT OF CANCER
  申请人：F. Hoffmann-Roche AG

  公开号：EP1791837A1

  公开（公告）日：2007-06-06