5-(methylethyl)spiro[1,3-dihydroisobenzofuran-3,4'-piperidine] hydrochloride | 644974-22-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: 5-(methylethyl)spiro[1,3-dihydroisobenzofuran-3,4'-piperidine] hydrochloride
• 英文别名: 6-propan-2-ylspiro[1H-2-benzofuran-3,4'-piperidine];hydrochloride
• CAS: 644974-22-1
• 化学式: C₁₅H₂₁NO*ClH
• 分子量: 267.799
• InChiKey: GIKHRJAKDTXWGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.34
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  21.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Spirocvclic piperidines as mch1 antagonists and uses thereof
  申请人：Marzabadi R Mohammad

  公开号：US20060173027A1

  公开（公告）日：2006-08-03

  This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject=s depression and/or anxiety. This invention further provides a method of treating a subject suffering from a urinary disorder.

  本发明涉及选择性拮抗黑色素浓集素-1（MCH1）受体的化合物。本发明提供一种制药组合物，包括本发明的化合物的治疗有效量和药学上可接受的载体。本发明提供了一种制备制药组合物的方法，包括将本发明的化合物的治疗有效量和药学上可接受的载体结合。本发明还提供了一种减轻受试者体重的方法，包括向受试者施用本发明的化合物的有效量以减轻受试者的体重。本发明还提供了一种治疗患有抑郁症和/或焦虑症的受试者的方法，包括向受试者施用本发明的化合物的有效量以治疗受试者的抑郁症和/或焦虑症。本发明还提供了一种治疗患有泌尿系统疾病的受试者的方法。
• US7335665B2
  申请人：——

  公开号：US7335665B2

  公开（公告）日：2008-02-26