3-(1,1-dioxo-7-pyridin-4-yl-2,3-dihydro-pyrazolo[5,1-b]thiazol-6-yl)-phenol | 1231737-21-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(1,1-dioxo-7-pyridin-4-yl-2,3-dihydro-pyrazolo[5,1-b]thiazol-6-yl)-phenol
• 英文别名: 3-(1,1-Dioxo-7-pyridin-4-yl-2,3-dihydropyrazolo[5,1-b][1,3]thiazol-6-yl)phenol
• CAS: 1231737-21-5
• 化学式: C₁₆H₁₃N₃O₃S
• 分子量: 327.364
• InChiKey: VHPIEKHXEFQERF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  93.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] BICYCLIC PYRAZOLES AS PROTEIN KINASE INHIBITORS<br/>[FR] PYRAZOLES BICYCLIQUES EN TANT QU'INHIBITEURS DE PROTÉINES KINASES
  申请人：NERVIANO MEDICAL SCIENCES SRL

  公开号：WO2010070060A1

  公开（公告）日：2010-06-24

  3,4-diaryl-bicyclicpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

  公开了规范中定义的式(I)的3,4-二芳基-双环吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物；发明的化合物可能在治疗中对治疗与蛋白激酶活性失调相关的疾病，如癌症，具有用处。
• BICYCLIC PYRAZOLES AS PROTEIN KINASE INHIBITORS
  申请人：Pulici Maurizio

  公开号：US20110257165A1

  公开（公告）日：2011-10-20

  3,4-diaryl-bicyclicpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

  本文揭示了式（I）中定义的3,4-二芳基-双环吡唑衍生物及其药学上可接受的盐，以及其制备方法和包含它们的制药组合物；本发明的化合物可能在治疗与蛋白激酶活性失调相关的疾病，如癌症方面有用。
• US8524707B2
  申请人：——

  公开号：US8524707B2

  公开（公告）日：2013-09-03