2-butyl-3-[4-(1H-tetrazol-5-yl)benzyl]-3H-imidazole-4-carboxylic acid ((R)-1-hydroxycarbamoylmethyl-3-methylbutyl)amide | 1073548-69-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-butyl-3-[4-(1H-tetrazol-5-yl)benzyl]-3H-imidazole-4-carboxylic acid ((R)-1-hydroxycarbamoylmethyl-3-methylbutyl)amide
• 英文别名: 2-butyl-N-[(3R)-1-(hydroxyamino)-5-methyl-1-oxohexan-3-yl]-3-[[4-(2H-tetrazol-5-yl)phenyl]methyl]imidazole-4-carboxamide
• CAS: 1073548-69-2
• 化学式: C₂₃H₃₂N₈O₃
• 分子量: 468.559
• InChiKey: IGSGKXJYTPTVPN-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  34
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  151
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• DUAL-ACTING ANTIHYPERTENSIVE AGENTS
  申请人：Allegretti Paul

  公开号：US20110281925A1

  公开（公告）日：2011-11-17

  The invention is directed to compounds having the formula: wherein: Ar, r, Y, Z, Q, W, X, and R 5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT 1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

  该发明涉及具有以下式子的化合物：其中：Ar、r、Y、Z、Q、W、X和R5-7如规范中所定义，并且其药学上可接受的盐。这些化合物具有AT1受体拮抗活性和酶解酶抑制活性。该发明还涉及包含这些化合物的制药组合物；使用这些化合物的方法；以及制备这些化合物的过程和中间体。
• DUAL-ACTING IMIDAZOLE ANTIHYPERTENSIVE AGENTS
  申请人：ALLEGRETTI Paul

  公开号：US20110092551A1

  公开（公告）日：2011-04-21

  The invention is directed to compounds having the formula: wherein: Ar, r, R 2-3 , X, and R 5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT 1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

  本发明涉及具有下式的化合物：其中：Ar，r，R2-3，X和R5-7如说明书所定义，以及其药学上可接受的盐。这些化合物具有AT1受体拮抗活性和酶解酶抑制活性。本发明还涉及包含这些化合物的制药组合物；使用这些化合物的方法；以及制备这些化合物的过程和中间体。
• US7879896B2
  申请人：——

  公开号：US7879896B2

  公开（公告）日：2011-02-01
• US8013005B2
  申请人：——

  公开号：US8013005B2

  公开（公告）日：2011-09-06
• US8158659B2
  申请人：——

  公开号：US8158659B2

  公开（公告）日：2012-04-17