N-(3-((4-cyanobenzyl)(4-(3-(hydroxymethyl)-5-((tetrahydrofuran-3-yl)methoxy)phenoxy)benzyl)amino)-2-methylphenyl)methanesulfonamide | 1264835-78-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-((4-cyanobenzyl)(4-(3-(hydroxymethyl)-5-((tetrahydrofuran-3-yl)methoxy)phenoxy)benzyl)amino)-2-methylphenyl)methanesulfonamide
• 英文别名: N-[3-[(4-cyanophenyl)methyl-[[4-[3-(hydroxymethyl)-5-(oxolan-3-ylmethoxy)phenoxy]phenyl]methyl]amino]-2-methylphenyl]methanesulfonamide
• CAS: 1264835-78-0
• 化学式: C₃₅H₃₇N₃O₆S
• 分子量: 627.761
• InChiKey: OJWCBZIBYKLBES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  45
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  130
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• NOVEL COMPOUNDS AS MODULATORS OF GLUCOCORTICOID RECEPTORS
  申请人：Thombare Pravin S.

  公开号：US20120220590A1

  公开（公告）日：2012-08-30

  Compounds of formula (I) and pharmaceutical compositions containing them are described. The use of the compounds and compositions are also described.

  描述了化合物(I)的结构和含有它们的药物组合物。还描述了这些化合物和组合物的用途。
• [EN] NOVEL COMPOUNDS AS MODULATORS OF GLUCOCORTICOID RECEPTORS<br/>[FR] NOUVEAUX COMPOSÉS COMME MODULATEURS DE RÉCEPTEURS GLUCOCORTICOÏDES
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2011016050A2

  公开（公告）日：2011-02-10

  The present invention relates to novel compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, pharmaceutical compositions containing them, use of these compounds in medicine and the intermediates involved in their preparation.