1-(3-(3-(3-(2-cyclohexylethyl)phenethyl)phenyl)-1,2,4-oxadiazol-5-yl)cyclopropanecarboximidamide hydrochloride | 1449764-76-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(3-(3-(3-(2-cyclohexylethyl)phenethyl)phenyl)-1,2,4-oxadiazol-5-yl)cyclopropanecarboximidamide hydrochloride
• 英文别名: 1-[3-[3-[2-[3-(2-Cyclohexylethyl)phenyl]ethyl]phenyl]-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide;hydrochloride
• CAS: 1449764-76-4
• 化学式: C₂₈H₃₄N₄O*ClH
• 分子量: 479.065
• InChiKey: DDFYQBPFBSYOLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.42
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  88.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• LONG CHAIN BASE SPHINGOSINE KINASE INHIBITORS
  申请人：UNIVERSITY OF VIRGINIA PATENT FOUNDATION

  公开号：US20150210675A1

  公开（公告）日：2015-07-30

  The invention relates to inhibitors of Sphingosine Kinase enzymatic activity, and methods of treating diseases and disorders by administering inhibitors of Sphingosine Kinase enzymatic activity.

  本发明涉及抑制鞘氨醇激酶酶活性的抑制剂，以及通过给予鞘氨醇激酶酶活性抑制剂治疗疾病和疾患的方法。
• US9688668B2
  申请人：——

  公开号：US9688668B2

  公开（公告）日：2017-06-27
• [EN] LONG CHAIN BASE SPHINGOSINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE LA KINASE SPHINGOSINE AVEC BASE À LONGUE CHAÎNE
  申请人：UNIVERSITY OF VIRGINIA PATENT FOUNDATION

  公开号：WO2013119946A1

  公开（公告）日：2013-08-15

  The invention relates to inhibitors of sphingosine kinase enzymatic activity, compounds and pharmaceutical compositions that inhibit sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) enzymes and further relates to methods of treating diseases and disorders mediated by sphingosine 1 phosphate activity, comprising administering an effective amount of sphingosine kinase inhibitors.