7-(二乙基氨基)-N-[3-(2,5-二氧代-2,5-二氢-1H-吡咯-1-基)丙基]-2-氧代-2H-苯并吡喃-3-甲酰胺 | 160291-54-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 7-(二乙基氨基)-N-[3-(2,5-二氧代-2,5-二氢-1H-吡咯-1-基)丙基]-2-氧代-2H-苯并吡喃-3-甲酰胺
• 英文名称: 7-diethylamino-N-(3-maleimidopropyl)-2-oxo-2H-chromene-3-carboxamide
• 英文别名: 7-Diethylamino-3-[N-(3-maleimidopropyl)carbamoyl]coumarin；7-(diethylamino)-N-[3-(2,5-dioxopyrrol-1-yl)propyl]-2-oxochromene-3-carboxamide
• CAS: 160291-54-3
• 化学式: C₂₁H₂₃N₃O₅
• 分子量: 397.431
• InChiKey: PHFIKYNYJRZPND-UHFFFAOYSA-N

物化性质

• 沸点：
  693.2±55.0 °C(Predicted)
• 密度：
  1.319±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  96
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 危险品标志：
  Xn
• 危险类别码：
  R22
• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  N-(3-aminopropyl)-7-(diethylamino)-2-oxo-2H-chromene-3-carboxamide 在 cobalt naphthenate 、 乙酸酐 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 2.33h， 生成 7-(二乙基氨基)-N-[3-(2,5-二氧代-2,5-二氢-1H-吡咯-1-基)丙基]-2-氧代-2H-苯并吡喃-3-甲酰胺
  参考文献：
  名称：

  Corrie, John E. T., Journal of the Chemical Society. Perkin transactions I, 1994, # 20, p. 2975 - 2982

  摘要：

  DOI：

文献信息

• SENSOR
  申请人：Medical Research Council

  公开号：EP2342216A1

  公开（公告）日：2011-07-13
• Light Activated Shape Memory Co-Polymers
  申请人：Tong Hung Tat

  公开号：US20080021166A1

  公开（公告）日：2008-01-24

  The present discovery uses monomers which contain reversible photo-crosslinkable groups in addition to primary polymerizable groups. The mechanical properties of these materials and the reversibility of the photo-activated shape memory effect demonstrate the effectiveness of using photo-irradiation to effect change in modulus and shape memory effect. In the preferred embodiment the reaction mixture includes a photo-reactive monomer comprising a photo reactive group and a polymerizable group; a second monomer, which is more preferably a mixture of monomers, which are acrylate based; a multi-functional crosslinking agent, preferably 1,6 hexanediol diacrylate (HDODA); an initiator, preferably a free radical initiator; and a fifth, optional, component which is a modifying polymer. The mixture of the second monomer, crosslinking agent, and initiator comprise the base polymer matrix into which the photo-reactive monomer is incorporated. The polymeriziable group of the photo reactive monomer allows the photo reactive monomer to polymerize with the base polymer matrix.
• US8754179B2
  申请人：——

  公开号：US8754179B2

  公开（公告）日：2014-06-17
• [EN] SENSOR<br/>[FR] CAPTEUR
  申请人：MEDICAL RES COUNCIL

  公开号：WO2010032001A1

  公开（公告）日：2010-03-25

  The invention relates to an ADP binding molecule comprising a polypeptide, said polypeptide comprising amino acid sequence corresponding to at least amino acids 11 to 310 of SEQ ID NO:1, wherein said polypeptide comprises a substitution relative to SEQ ID NO:1 at amino acid C287, and wherein said polypeptide comprises a further cysteine residue for attachment of at least one reporter moiety, and wherein said polypeptide has at least 68% sequence identity to SEQ ID NO:1 at the amino acid residues corresponding to those shown in column III of table A.