methyl 2-acetoxy-2-(4-pentyn-1-oxy)acetate | 121223-13-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 2-acetoxy-2-(4-pentyn-1-oxy)acetate
• 英文别名: Methyl (acetyloxy)(4-pentynyloxy)acetate；methyl 2-acetyloxy-2-pent-4-ynoxyacetate
• CAS: 121223-13-0
• 化学式: C₁₀H₁₄O₅
• 分子量: 214.218
• InChiKey: FDKDOSDJYRKRLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 2-acetoxy-2-(4-pentyn-1-oxy)acetate 在 四氯化锡 作用下， 以 二氯甲烷 为溶剂， 以43%的产率得到2-carbomethoxy-4-chloro-2,5,6,7-tetrahydrooxepin
  参考文献：
  名称：

  Synthesis of oxacyclic carboxylic esters by way of methoxycarbonyloxonium ions; Evidence for a cationic oxa-cope rearrangement

  摘要：

  DOI：

  10.1016/s0040-4039(00)82348-5
• 作为产物：
  描述：

  4-戊炔-1-醇 、 乙酸酐 、 methyl glyoxylate hydrate 在 4-二甲氨基吡啶 作用下， 生成 methyl 2-acetoxy-2-(4-pentyn-1-oxy)acetate
  参考文献：
  名称：

  Synthesis of oxacyclic carboxylic esters by way of methoxycarbonyloxonium ions; Evidence for a cationic oxa-cope rearrangement

  摘要：

  DOI：

  10.1016/s0040-4039(00)82348-5

文献信息

• π-Cyclizations of α-methoxycarbonyl oxycarbenium ions; synthesis of oxacyclic carboxylic esters
  作者：Lucie D.M. Lolkema、Henk Hiemstra、Cindy Semeyn、W.Nico Speckamp

  DOI：10.1016/s0040-4020(01)85238-8

  日期：1994.1

  Acid-mediated cyclization reactions are described of seven methyl 2-acetoxy-2-(3-alken-1-oxy)acetates with different chain substitution. The major product of the tin tetrachloride-induced cyclization reaction is in most cases a tetrahydropyran containing an equatorial carbomethoxy function at C2 and an axial chlorine atom at C4. The mechanism of its formation involves a net cis-addition of the intermediate alpha-ester oxycarbenium ion to the carbon-carbon double bond, most likely caused by a quasi axial orientation of the ester function in a chair-like transition state. The results are interpreted by invoking (1) the occurrence of a 2-oxonia-Cope rearrangement and (2) the participation of the ester function in the mechanism of cyclization by trapping the cyclic cationic intermediate. The cyclizations of two methyl 2-acetoxy-2-(4-alken-1-oxy)acetates and two methyl 2-acetoxy-2-(alkynoxy)acetates are also described .
• LOLKEMA, LUCIE D. M.;HIEMSTRA, HENK;MOOIWEER, HENDRIK H.;SPECKAMP, W. NIC+, TETRAHEDRON LETT., 29,(1988) N 48, C. 6365-6368
  作者：LOLKEMA, LUCIE D. M.、HIEMSTRA, HENK、MOOIWEER, HENDRIK H.、SPECKAMP, W. NIC+

  DOI：——

  日期：——