3,5-bis(triisopropylsilylethynyl)benzyl azide | 1239921-62-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-bis(triisopropylsilylethynyl)benzyl azide
• 英文别名: 2-[3-(Azidomethyl)-5-[2-tri(propan-2-yl)silylethynyl]phenyl]ethynyl-tri(propan-2-yl)silane；2-[3-(azidomethyl)-5-[2-tri(propan-2-yl)silylethynyl]phenyl]ethynyl-tri(propan-2-yl)silane
• CAS: 1239921-62-0
• 化学式: C₂₉H₄₇N₃Si₂
• 分子量: 493.883
• InChiKey: OUQMLSGTIGYGCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.64
• 重原子数：
  34
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  14.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,3,5-三乙炔苯 、 3,5-bis(triisopropylsilylethynyl)benzyl azide 在 copper(ll) sulfate pentahydrate 、 sodium ascorbate 作用下， 以 四氢呋喃 、 水 、 N,N-二甲基甲酰胺 为溶剂， 以96.1%的产率得到2-[3-[[4-[3,5-Bis[1-[[3,5-bis[2-tri(propan-2-yl)silylethynyl]phenyl]methyl]triazol-4-yl]phenyl]triazol-1-yl]methyl]-5-[2-tri(propan-2-yl)silylethynyl]phenyl]ethynyl-tri(propan-2-yl)silane
  参考文献：
  名称：

  Designing dendritic frameworks using versatile building blocks suitable for CuI-catalyzed alkyne azide ‘click’ chemistry

  摘要：

  Synthesis of molecular building blocks that incorporate azide and alkyne-terminated functionalities suitable for Cu-I-catalyzed cycloaddition between alkynes and azides is reported. Their utility in constructing dendritic frameworks with 4, 6, or 12 peripheral acetylene groups using either the convergent or divergent methodology, and their functionalization with desirable end groups are demonstrated. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.05.061
• 作为产物：
  描述：

  3,5-bis(triisopropylsilylethynyl)benzyl bromide 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以96.4%的产率得到3,5-bis(triisopropylsilylethynyl)benzyl azide
  参考文献：
  名称：

  Designing dendritic frameworks using versatile building blocks suitable for CuI-catalyzed alkyne azide ‘click’ chemistry

  摘要：

  Synthesis of molecular building blocks that incorporate azide and alkyne-terminated functionalities suitable for Cu-I-catalyzed cycloaddition between alkynes and azides is reported. Their utility in constructing dendritic frameworks with 4, 6, or 12 peripheral acetylene groups using either the convergent or divergent methodology, and their functionalization with desirable end groups are demonstrated. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.05.061

文献信息

• Designing dendritic frameworks using versatile building blocks suitable for CuI-catalyzed alkyne azide ‘click’ chemistry
  作者：Rami Hourani、Anjali Sharma、Ashok Kakkar

  DOI：10.1016/j.tetlet.2010.05.061

  日期：2010.7

  Synthesis of molecular building blocks that incorporate azide and alkyne-terminated functionalities suitable for Cu-I-catalyzed cycloaddition between alkynes and azides is reported. Their utility in constructing dendritic frameworks with 4, 6, or 12 peripheral acetylene groups using either the convergent or divergent methodology, and their functionalization with desirable end groups are demonstrated. (C) 2010 Elsevier Ltd. All rights reserved.