8-(5-Methyl-2-phenyl-oxazol-4-yl)-2-pyrrol-1-yl-oct-4-ynoic acid | 610797-75-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 8-(5-Methyl-2-phenyl-oxazol-4-yl)-2-pyrrol-1-yl-oct-4-ynoic acid
• 英文别名: 8-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)-2-pyrrol-1-yloct-4-ynoic acid
• CAS: 610797-75-6
• 化学式: C₂₂H₂₂N₂O₃
• 分子量: 362.428
• InChiKey: MJGVTNRKRHRJHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  68.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• ANTIDIABETIC AGENTS
  申请人：——

  公开号：US20030220381A1

  公开（公告）日：2003-11-27

  Compounds of formula I: 1 wherein X, Y, B, E, J, K, L, Z, and R 9 -R 12 have any of the meanings described herein, their pharmaceutically acceptable salts, lower blood glucose levels and are useful for treating diseases in mammals such as Non-Insulin Dependent Diabetes Mellitus. Also disclosed are pharmaceutical compositions, processes for preparing compounds of formula (I) and intermediates useful for preparing compounds of formula I.

  公式I：1的化合物，在其中X、Y、B、E、J、K、L、Z和R9-R12具有本文所描述的任何含义，它们的药学上可接受的盐，可以降低血糖水平，并且对治疗哺乳动物的疾病如非胰岛素依赖型糖尿病是有用的。还公开了制药组合物、制备公式(I)化合物的方法以及制备公式I化合物的有用中间体。
• US6696474B2
  申请人：——

  公开号：US6696474B2

  公开（公告）日：2004-02-24
• [EN] ANTIDIABETIC AGENTS<br/>[FR] AGENTS ANTIDIABETIQUES
  申请人：WARNER LAMBERT CO

  公开号：WO2003082276A1

  公开（公告）日：2003-10-09

  Compounds of formula (I): wherein X, Y, B, E, J, K, L, Z, and R9-R12 have any of the meanings described herein, their pharmaceutically acceptable salts, lower blood glucose levels and are useful for treating diseases in mammals such as Non-Insulin Dependent Diabetes Mellitus. Also disclosed are pharmaceutical compositions, process for preparing compounds of formula (I) and intermediates useful for preparing compounds of formula (I).