9-methoxy-2-phenyl-6-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-4-(3,4,5-trimethoxyphenyl)-6H-pyrrolo[3,4-c]carbazole-1,3-dione | 633337-74-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 9-methoxy-2-phenyl-6-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-4-(3,4,5-trimethoxyphenyl)-6H-pyrrolo[3,4-c]carbazole-1,3-dione
• CAS: 633337-74-3
• 化学式: C₄₄H₄₂N₂O₁₅
• 分子量: 838.822
• InChiKey: DALNEFAMYGMVQS-HWKBMMEQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.55
• 重原子数：
  61.0
• 可旋转键数：
  12.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  193.66
• 氢给体数：
  0.0
• 氢受体数：
  16.0

反应信息

• 作为反应物：
  描述：

  9-methoxy-2-phenyl-6-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-4-(3,4,5-trimethoxyphenyl)-6H-pyrrolo[3,4-c]carbazole-1,3-dione 在 ammonium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 4.0h， 以39%的产率得到9-methoxy-6-α-D-glucopyranosyl-4-(3,4,5-trimethoxyphenyl)-6H-pyrrolo[3,4-c]carbazole-1,3-dione
  参考文献：
  名称：

  Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues

  摘要：

  An array of 4-(aryl or indolyl)pyrrolo[3,4-c]carbazole-1,3-diones (open analogues of indolocarbazole alkaloids), 10-(aryl or indolyl)pyrrolo [3,4-b]carbazole-1,3-diones, and different derivatives have been prepared using a Diels-Alder plus Fischer indolization approach and tested as cytotoxic agents. Some representative compounds display interesting cytotoxic profiles. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00308-0
• 作为产物：
  描述：

  (+/-)-(3aS,4S,10cS)-2-phenyl-9-methoxy-4-(3,4,5-trimethoxyphenyl)-3a,4,5,10c-tetrahydro-6H-pyrrolo[3,4-c]carbazole-1,3-dione 在 2,3-二氯-5,6-二氰基-1,4-苯醌 、 silver(l) oxide 作用下， 以 苯 为溶剂， 反应 3.0h， 生成 9-methoxy-2-phenyl-6-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-4-(3,4,5-trimethoxyphenyl)-6H-pyrrolo[3,4-c]carbazole-1,3-dione
  参考文献：
  名称：

  Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues

  摘要：

  An array of 4-(aryl or indolyl)pyrrolo[3,4-c]carbazole-1,3-diones (open analogues of indolocarbazole alkaloids), 10-(aryl or indolyl)pyrrolo [3,4-b]carbazole-1,3-diones, and different derivatives have been prepared using a Diels-Alder plus Fischer indolization approach and tested as cytotoxic agents. Some representative compounds display interesting cytotoxic profiles. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00308-0