ethyl 2-(acetylamino)-4-{2-[4-({(Z)-[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)phenyl]ethyl}-1,3-thiazole-5-carboxylate | 740816-44-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 2-(acetylamino)-4-{2-[4-({(Z)-[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)phenyl]ethyl}-1,3-thiazole-5-carboxylate
• 英文别名: Ethyl 2-acetamido-4-[2-[4-[bis[(2-methylpropan-2-yl)oxycarbonylamino]methylideneamino]phenyl]ethyl]-1,3-thiazole-5-carboxylate
• CAS: 740816-44-8
• 化学式: C₂₇H₃₇N₅O₇S
• 分子量: 575.686
• InChiKey: PMRAVLHJWAHGNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  40
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  186
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Thiazole derivatives
  申请人：Inoue Takayuki

  公开号：US20060128770A1

  公开（公告）日：2006-06-15

  A compound of the formula (I): R 1 —NH—X—Y-Z (I) wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a mammal, and the like.

  化合物公式(I): R1—NH—X—Y-Z (I)，其中每个符号如规范所定义，或其药学上可接受的盐，可用作血管黏附蛋白-1（VAP-1）抑制剂，制备一种制药组合物，一种预防或治疗VAP-1相关疾病（尤其是黄斑水肿）的方法，该方法包括向哺乳动物投与化合物或其药学上可接受的盐的有效量等。
• Method for treating vascular hyperpermeable disease
  申请人：Ueno Ryuji

  公开号：US20060229346A1

  公开（公告）日：2006-10-12

  The present invention provides a method for treating a vascular hyperpermeable disease (except macular edema), which method comprises administering to a patient in need thereof a vascular adhesion protein-1 (VAP-1) inhibitor in an amount sufficient to treat said patient for said disease. The agents are 2-acylamino thiazole compounds.

  本发明提供了一种治疗血管过渗性疾病（除黄斑水肿外）的方法，该方法包括向需要治疗该疾病的患者施用足量的血管粘附蛋白-1（VAP-1）抑制剂。该抑制剂为2-酰胺基噻唑类化合物。
• METHOD FOR TREATING VASCULAR HYPERPERMEABLE DISEASE
  申请人：UENO Ryuji

  公开号：US20080119462A1

  公开（公告）日：2008-05-22

  The present invention provides a method for treating a vascular hyperpermeable disease (except macular edema), which method comprises administering to a patient in need thereof a vascular adhesion protein-1 (VAP-1) inhibitor in an amount sufficient to treat said patient for said disease.

  本发明提供了一种治疗血管过渗性疾病（除了黄斑水肿）的方法，该方法包括向需要治疗该疾病的患者施用足够治疗该疾病的血管粘附蛋白-1（VAP-1）抑制剂。
• US7125901B2
  申请人：——

  公开号：US7125901B2

  公开（公告）日：2006-10-24
• US7442715B2
  申请人：——

  公开号：US7442715B2

  公开（公告）日：2008-10-28