[1-(2-Morpholin-4-ylethyl)indol-3-yl] acetate | 1023731-64-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: [1-(2-Morpholin-4-ylethyl)indol-3-yl] acetate
• CAS: 1023731-64-7
• 化学式: C₁₆H₂₀N₂O₃
• 分子量: 288.346
• InChiKey: WNJZFVIJUKGTLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  43.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  吲哚乙酸酯 、 N-(2-氯乙基)吗啉盐酸盐 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 以67%的产率得到[1-(2-Morpholin-4-ylethyl)indol-3-yl] acetate
  参考文献：
  名称：

  Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: Novel agonists for the CB1 receptor

  摘要：

  An exploratory chemical effort has been undertaken to develop a novel series of compounds as selective CB1 agonists. It is hoped that compounds of this type will have clinical utility in pain control, and cerebral ischaemia following stroke or traumatic head injury.We report here medicinal chemistry studies directed towards the investigation of a series of 1-substituted-indole-3-oxadiazoles as potential CB, agonists. Crown Copyright (c) 2007 Published by Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.04.007

文献信息

• Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: Novel agonists for the CB1 receptor
  作者：Gerard P. Moloney、James A. Angus、Alan D. Robertson、Martin J. Stoermer、Michael Robinson、Christine E. Wright、Ken McRae、Arthur Christopoulos

  DOI：10.1016/j.ejmech.2007.04.007

  日期：2008.3

  An exploratory chemical effort has been undertaken to develop a novel series of compounds as selective CB1 agonists. It is hoped that compounds of this type will have clinical utility in pain control, and cerebral ischaemia following stroke or traumatic head injury.We report here medicinal chemistry studies directed towards the investigation of a series of 1-substituted-indole-3-oxadiazoles as potential CB, agonists. Crown Copyright (c) 2007 Published by Elsevier Masson SAS. All rights reserved.