4,5,6,7-Tetrahydro-1H-1,3-benzodiazol-2-amine hydrochloride | 40639-89-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4,5,6,7-Tetrahydro-1H-1,3-benzodiazol-2-amine hydrochloride
• 英文别名: 4,5,6,7-tetrahydro-1H-benzimidazol-2-amine;hydrochloride
• CAS: 40639-89-2
• 化学式: C7H12ClN3
• mdl: MFCD27500766
• 分子量: 173.64
• InChiKey: AYOBXRTVMOGKGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  54.7
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• Novel substituted 2-aminoimidazoles, process for their preparation, their use as medicament or diagnostic aid
  申请人：Aventis Pharma Deutschland GmbH

  公开号：US20040259927A1

  公开（公告）日：2004-12-23

  Novel substituted 2-aminoimidazoles of formula I, process for their preparation, their use as medicament or diagnostic aid, and medicament containing them. The compounds of this type are useful in the prevention or treatment of various disorders and can be employed inter alia for renal disorders such as acute or chronic renal failure, for disorders of biliary function, for respiratory disorders such as snoring or sleep apneas or for stroke. 1

  本发明涉及一种化合物，即式I的2-氨基咪唑的替代物，以及它们的制备方法、作为药物或诊断辅助剂的用途和含有它们的药物。这种化合物可用于预防或治疗各种疾病，并可用于肾功能障碍，如急性或慢性肾衰竭，胆功能障碍，呼吸障碍，如打鼾或睡眠呼吸暂停以及中风等疾病的治疗。
• NOVEL SUBSTITUTED 2-AMINOIMIDAZOLES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENT OR DIAGNOSTIC AID
  申请人：HEINELT Uwe

  公开号：US20080275098A1

  公开（公告）日：2008-11-06

  The present invention comprises novel substituted 2-aminoimidazoles of formula I, processes for their preparation, pharmaceutical compositions thereof, and methods for their use in the treatment of disorders of the central nervous system, cardiovascular disorders, stroke and pulmonary disorders, urinary disorders such as acute or chronic renal failure, disorders of biliary function, respiratory disorders such as snoring or sleep apnea. wherein the substitutents R1-R8 are further defined herein.

  本发明涉及公式I的新型取代2-氨基咪唑衍生物，其制备方法、药物组合物以及在中枢神经系统、心血管疾病、中风和肺部疾病、急性或慢性肾功能衰竭、胆功能障碍、打鼾或睡眠呼吸暂停等呼吸系统疾病和泌尿系统疾病的治疗方法，其中取代基R1-R8在此进一步定义。
• US7442717B2
  申请人：——

  公开号：US7442717B2

  公开（公告）日：2008-10-28