2-(β-Phenylaethylamino)-thiazol | 91088-91-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(β-Phenylaethylamino)-thiazol
• 英文别名: N-(2-phenylethyl)-1,3-thiazol-2-amine
• CAS: 91088-91-4
• 化学式: C₁₁H₁₂N₂S
• mdl: MFCD11121221
• 分子量: 204.296
• InChiKey: JRFFAPQYMPSJBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] CONJUGATES OF THE B-SUBUNIT OF SHIGA TOXIN FOR ANTICANCER THERAPIES<br/>[FR] CONJUGUÉS DE LA SOUS-UNITÉ B DE TOXINE DE SHIGA POUR DES THÉRAPIES ANTICANCÉREUSES
  申请人：INST CURIE

  公开号：WO2014086952A1

  公开（公告）日：2014-06-12

  Conjugates or pharmaceutical compositions comprising conjugates of the B-subunit of Shiga toxin that are useful for cancer therapies are disclosed. More specifically, the pharmaceutical compositions comprise STxB conjugated to at least one antimitotic agent such as auristatin or pharmaceutically acceptable salts thereof through a bifunctional linker. Processes to make the conjugates, as well as methods to treat cancers are also disclosed.

  披露了用于癌症治疗的志贺毒素B亚单位偶联物或药物组合物。更具体地说，药物组合物包含通过双功能连接剂与至少一种抗有丝分裂剂如auriSTatin或药用可接受盐偶联的STxB。还披露了制造偶联物的方法以及治疗癌症的方法。
• Conjugates of the B-subunit of Shiga toxin for anticancer therapies
  申请人：Institut Curie

  公开号：EP2740493A1

  公开（公告）日：2014-06-11

  Conjugates or pharmaceutical compositions comprising conjugates of the B-subunit of Shiga toxin that are useful for cancer therapies are disclosed. More specifically, the pharmaceutical compositions comprise STxB conjugated to at least one antimitotic agent such as auristatin or pharmaceutically acceptable salts thereof through a bifunctional linker. Processes to make the conjugates, as well as methods to treat cancers are also disclosed.

  披露了用于癌症治疗的B亚单位志贺毒素偶联物或药物组合物。更具体地说，药物组合物包括通过双功能连接剂将STxB偶联至少一种抗有丝分裂剂，如auriSTatin或药用可接受盐。还披露了制造偶联物的方法以及治疗癌症的方法。
• PENTAPEPTIDE COMPOUNDS AND USES RELATED THERETO
  申请人：Senter D. Peter

  公开号：US20050009751A1

  公开（公告）日：2005-01-13

  Pentapeptide compounds are disclosed. The compounds have biological activity, e.g., cytotoxicity. Prodrugs having targeting groups and pentapeptide moieities, as well as precursors thereof are also disclosed. For example, precursors having a reactive linker that can serve as a reaction site for joining to a targeting agent, e.g., an antibody, as disclosed.

  本文披露了五肽化合物。这些化合物具有生物活性，例如细胞毒性。此外，本文还披露了具有靶向基团和五肽基团的前药及其前体。例如，本文披露了具有反应性连接剂的前体，该连接剂可用作与靶向剂（例如抗体）结合的反应位点。
• Pentapeptide compounds and uses related thereto
  申请人：——

  公开号：US20040157782A1

  公开（公告）日：2004-08-12

  Pentapeptide compounds are disclosed. The compounds have biological activity, e.g., cytotoxicity. Prodrugs having targeting groups and pentapeptide moieities, as well as precursors thereof are also disclosed. For example, precursors having a reactive linker that can serve as a reaction site for joining to a targeting agent, e.g., an antibody, as disclosed.

  本发明公开了五肽化合物。这些化合物具有生物活性，例如细胞毒性。还公开了具有靶向基团和五肽基团的前药以及其前体。例如，公开了具有反应性连接剂的前体，该连接剂可以作为连接到靶向剂（例如抗体）的反应位点。
• PHENYL THIAZOLE DERIVATIVES WITH ANTI HERPES VIRUS PROPERTIES
  申请人：BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

  公开号：EP0871619A1

  公开（公告）日：1998-10-21