| 1309604-06-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1309604-06-5
• 化学式: C₁₅H₁₉ClO₂
• 分子量: 266.768
• InChiKey: LDLUOISBVFFMBX-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 四氧化锇 、 caesium carbonate 、 N-甲基吗啉氧化物 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 15.0h， 生成
  参考文献：
  名称：

  Highly Stereocontrolled and Regiocontrolled Syntheses of 2,3,4-Trisubstituted Alkanoates and Lactones

  摘要：

  New chlorodiols (+/-)-3 and (+/-)-5 are densely functionalized and versatile synthons. They are converted in one step on a gram scale into 2-chlorolactones (+/-)-6 and (+/-)-7 and into 4-hydroxy glycidate esters (+/-)-9 and (+/-)-10. The 4-hydroxy glycidate esters (+/-)-9 and (+/-)-10 are converted stereospecifically and regiospecifically into oxazolines (+/-)-13 and (+/-)-14 and into cyclic carbamates (+/-)-18 (+/-)-20. The 4-hydroxy glycidate ester (+/-)-10 undergoes stereocontrolled and regiocontrolled epoxide opening by sodium azide to form the 2-azido-3,4-dihydroxy alkanoate (+/-)-21. Finally, chlorodiol (+/-)-5 reacts stereospecifically with silver triflate to form the 2,3-dihydroxyfuranone (+/-)-26.

  DOI：

  10.1021/jo200795f