ethyl 2-(2-chloro-5-fluorophenyl)imidazo[1,2-a]pyrimidine-3-carboxylate | 1426521-30-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 2-(2-chloro-5-fluorophenyl)imidazo[1,2-a]pyrimidine-3-carboxylate
• CAS: 1426521-30-3
• 化学式: C₁₅H₁₁ClFN₃O₂
• 分子量: 319.723
• InChiKey: JOWDQPVIPNYKCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  56.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• BICYCLIC AGONISTS OF GPR131 AND USES THEREOF
  申请人：SONG Jiangao

  公开号：US20130059845A1

  公开（公告）日：2013-03-07

  The present disclosure relates to compounds that act as agonists of, or otherwise modulate the activity of, GPR131 and to their use in the treatment of various diseases. In particular embodiments, the structure of the compounds is given by Formula I: wherein the variables are as described herein. Related compositions, formulations and methods for the preparation of compounds of formula I are also described.

  本公开涉及作为GPR131的激动剂或以其他方式调节其活性的化合物，以及它们在治疗各种疾病中的应用。在特定实施例中，化合物的结构由公式I给出：其中变量如本文所述。还描述了与公式I化合物的相关组合物、配方和制备方法。
• US9593109B2
  申请人：——

  公开号：US9593109B2

  公开（公告）日：2017-03-14
• [EN] BICYCLIC AGONISTS OF GPR131 AND USES THEREOF<br/>[FR] AGONISTES BICYCLIQUES DE GPR131 ET LEURS UTILISATIONS
  申请人：METABOLEX INC

  公开号：WO2013032939A1

  公开（公告）日：2013-03-07

  The present disclosure relates to compounds that act as agonists of, or otherwise modulate the activity of, GPR131 and to their use in the treatment of various diseases. In particular embodiments, the structure of the compounds is given by Formula I: wherein the variables are as described herein. Related compositions, formulations and methods for the preparation of compounds of formula I are also described.