2,4-bis(4-bromophenyl)-2,7,8-trimethyl-2,3-dihydro-1H-benzo[b][1,4]diazepine | 1369787-54-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 2,4-bis(4-bromophenyl)-2,7,8-trimethyl-2,3-dihydro-1H-benzo[b][1,4]diazepine
• 英文别名: 2,4-Bis(4-bromophenyl)-2,7,8-trimethyl-1,3-dihydro-1,5-benzodiazepine；2,4-bis(4-bromophenyl)-2,7,8-trimethyl-1,3-dihydro-1,5-benzodiazepine
• CAS: 1369787-54-1
• 化学式: C₂₄H₂₂Br₂N₂
• 分子量: 498.26
• InChiKey: XYXWSVXIZHFTEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (4-溴苯基)乙炔 、 4，5-二甲基-1，2-苯二胺 在 mercuric triflate 作用下， 以 乙醇 为溶剂， 反应 1.5h， 以92%的产率得到2,4-bis(4-bromophenyl)-2,7,8-trimethyl-2,3-dihydro-1H-benzo[b][1,4]diazepine
  参考文献：
  名称：

  Terminal alkynes as keto-methyl equivalent toward one pot synthesis of 1,5-benzodiazepine derivatives under catalysis of Hg(OTf)2

  摘要：

  Mercuric triflate catalyzes the reaction between 1,2-diaminobenzene and terminal alkynes to afford 2,4-disubstituted 2-methyl-2,3-dihydro-1H-benzo[b][1,4]diazepine in an excellent yield. The terminal alkynes function as a source of keto-methyl equivalent. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.01.036

文献信息

• Graphite oxide: a metal free highly efficient carbocatalyst for the synthesis of 1,5-benzodiazepines under room temperature and solvent free heating conditions
  作者：Ramen Jamatia、Ajay Gupta、Binoyargha Dam、Mithu Saha、Amarta Kumar Pal

  DOI：10.1039/c6gc03110b

  日期：——

  We report a sustainable and metal free carbocatalyst, graphite oxide, for the synthesis of 1,5-benzodiazepines under room temperature and solvent free heating conditions.

  我们报告了一种在室温和无溶剂加热条件下合成1,5-苯并二氮杂pine的可持续且无金属的碳催化剂，氧化石墨。
• A green and sustainable approach for the synthesis of 1,5-benzodiazepines and spirooxindoles in one-pot using a MIL-101(Cr) metal–organic framework as a reusable catalyst
  作者：Fillip Kumar Sarkar、Ajay Gupta、Ramen Jamatia、Jasha Momo H. Anal、Amarta Kumar Pal

  DOI：10.1039/d1nj03176g

  日期：——

  MIL-101(Cr) has been efficiently utilized for the synthesis of biologically relevant heterocycles such as 1,5-benzodiazepines and spirooxindoles in one-pot. MIL-101(Cr) was prepared via a solvothermal method and characterized by FT-IR, PXRD, SEM, TEM, EDX, and ICP-OES analysis. Thermogravimetric analysis (TGA) described its high thermal stability. Low catalyst loading, easy separation, reusability, and high

  金属-有机骨架 MIL-101(Cr) 已被有效地用于合成生物相关的杂环，如 1,5-苯二氮卓类和螺环吲哚。MIL-101(Cr) 是通过溶剂热法制备的，并通过 FT-IR、PXRD、SEM、TEM、EDX 和 ICP-OES 分析进行表征。热重分析 (TGA) 描述了其高热稳定性。低催化剂负载、易于分离、可重复使用和高产率是该协议的一些显着特点。无溶剂反应条件 (SFRC) 或水作为溶剂是绿色和可持续工艺开发领域的一些额外优势。
• Terminal alkynes as keto-methyl equivalent toward one pot synthesis of 1,5-benzodiazepine derivatives under catalysis of Hg(OTf)2
  作者：Gourhari Maiti、Utpal Kayal、Rajiv Karmakar、Rudraksha N. Bhattacharya

  DOI：10.1016/j.tetlet.2012.01.036

  日期：2012.3

  Mercuric triflate catalyzes the reaction between 1,2-diaminobenzene and terminal alkynes to afford 2,4-disubstituted 2-methyl-2,3-dihydro-1H-benzo[b][1,4]diazepine in an excellent yield. The terminal alkynes function as a source of keto-methyl equivalent. (C) 2012 Elsevier Ltd. All rights reserved.